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首页> 外文期刊>Journal of orthopaedic research >Mechanical differences between lumbar and tail discs in the mouse.
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Mechanical differences between lumbar and tail discs in the mouse.

机译：鼠标中腰椎间盘和尾椎间盘的机械差异。

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The mouse lumbar and tail discs are both used as models to study disc degeneration; however, the mechanical behavior of these two levels has not been compared. The objective of this study was to compare the elastic and viscoelastic mechanical properties of lumbar and tail discs of the mouse under axial compression-tension loading. We hypothesized that tail discs would have a larger transition zone (e.g., neutral zone) and would be less stiff in compression. To test these hypotheses, lumbar and tail bone-disc-bone motion segments were loaded in axial compression and tension. The nonlinear elastic mechanical behavior was examined using a tri-linear curvefit. Elastic behavior of lumbar and tail discs was most different in the low-stiffness transition region (neutral zone), where lumbar discs were nearly twice as stiff over half the axial displacement. In addition, viscoelastic behavior, which was examined using a stretch-exponential curvefit, also showed large lumbar and tail differences, where lumbar discs compressed by 60% of their original height and tail discs by 98% after static creep compression. These results demonstrate that tail discs undergo far more axial displacement than lumbar discs under the same load. These findings are relevant to rodent tail models where chronic loads are applied in vivo to study mechanical pathways of degeneration. Furthermore, the tri-linear model, used here to curvefit the nonlinear compression-tension data, quantified stiffness in the transition zone for the first time, which may prove useful in future disc mechanical studies.
机译：小鼠腰椎间盘和尾椎间盘均用作研究椎间盘退变的模型。但是，这两个级别的机械性能尚未进行比较。这项研究的目的是比较在轴向压缩-拉伸载荷下小鼠腰椎和尾椎间盘的弹性和粘弹性力学性能。我们假设尾盘将具有较大的过渡区域（例如中性区域），并且压缩时的刚性较小。为了检验这些假设，对腰椎和尾椎间盘椎骨的运动节段进行轴向压缩和拉伸。使用三线性曲线拟合检查了非线性弹性力学行为。腰椎间盘和尾椎间盘的弹性行为在低刚度过渡区域（中性区）差异最大，在该区域中，腰椎间盘的硬度几乎是轴向位移的一半的两倍。此外，通过拉伸指数曲线拟合检查的粘弹性行为也显示出较大的腰椎和尾椎差异，其中腰椎间盘在静态蠕变压缩后压缩了其原始高度的60％，而尾椎间盘则压缩了其原始高度的98％。这些结果表明，在相同载荷下，尾椎间盘比腰椎间盘承受更大的轴向位移。这些发现与啮齿动物的尾巴模型有关，在啮齿类动物的尾巴模型中，将体内长期负荷应用于研究退化的机械途径。此外，用于线性拟合非线性压缩张力数据的三线性模型首次量化了过渡区的刚度，这可能在未来的椎间盘力学研究中很有用。

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