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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Soluble TNF-alpha receptor 2 produced by alternative splicing is paradoxically associated with markers of liver injury.
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Soluble TNF-alpha receptor 2 produced by alternative splicing is paradoxically associated with markers of liver injury.

机译：通过选择性剪接产生的可溶性TNF-α受体2与肝损伤的标志物反常相关。

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摘要

Tumor necrosis factor-alpha and insulin resistance play central roles in the pathogenesis of abnormal hepatocellular function. We evaluate the relationship between a novel serum DS-TNFR2 (an alternatively spliced soluble TNF-alpha receptor 2) isoform and parameters of liver health. Serum ALT, AST and GGT, insulin resistance, adiponectin and DS-TNFR2 isoform concentrations were measured in 492 subjects from two different Caucasian Spanish populations. We found a significant negative association between serum ALT and DS-TNFR2 levels in both populations (r=-0.269; p=0.002 and r=-0.152; p=0.01, respectively). DS-TNFR2 levels also correlated negatively with serum AST (r=-0.142; p=0.042) and GGT (r=-0.206; p=0.003) in population 1 and with AST (r=-0.127; p=0.038) in population 2. In multiple regression analysis models, serum DS-TNFR2 was shown to be an independent modulator of serum ALT activity after adjusting for sex, age, BMI, HOMA and adiponectin in both populations. These results suggest potential anti-inflammatory properties of this TNF-alpha receptor 2 isoform at the hepatic level.
机译：肿瘤坏死因子-α和胰岛素抵抗在异常肝细胞功能的发病机理中起着核心作用。我们评估新型血清DS-TNFR2（或选择性剪接可溶性TNF-α受体2）亚型与肝脏健康参数之间的关系。在来自两个不同的西班牙白种人人群的492位受试者中测量了血清ALT，AST和GGT，胰岛素抵抗，脂联素和DS-TNFR2亚型的浓度。我们在两个人群中发现血清ALT和DS-TNFR2水平之间显着负相关（分别为r = -0.269; p = 0.002和r = -0.152; p = 0.01）。 DS-TNFR2水平也与人群1中的血清AST（r = -0.142; p = 0.042）和GGT（r = -0.206; p = 0.003）和人群AST（r = -0.127; p = 0.038）呈负相关2.在多元回归分析模型中，在调整了两个人群的性别，年龄，BMI，HOMA和脂联素后，血清DS-TNFR2被证明是血清ALT活性的独立调节剂。这些结果表明该TNF-α受体2亚型在肝脏中的潜在抗炎特性。

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