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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Increased IFN-gamma production by NK and CD3+/CD56+ cells in sexually HIV-1-exposed but uninfected individuals.
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Increased IFN-gamma production by NK and CD3+/CD56+ cells in sexually HIV-1-exposed but uninfected individuals.

机译：在性接触HIV-1但未感染的个体中，NK和CD3 + / CD56 +细胞产生的IFN-γ产生增加。

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摘要

The mechanisms involved in controlling the establishment of HIV-1 infection are not fully understood. In particular, the role of innate immunity in natural resistance exhibited by individuals who are continuously exposed to HIV-1 but remain seronegative (ESN) has not been thoroughly evaluated. We determined the frequency and function of peripheral blood innate immune cells (plasmacytoid and myeloid dendritic cells, monocytes, NK cells, CD3+/CD56+ cells and invariant NKT cells) in ESN, chronically HIV-1-infected and low-risk HIV-1 seronegative individuals. ESN demonstrated a similar frequency of innate immune cells in comparison to controls and a higher frequency of dendritic cells, NK and invariant NKT cells compared to HIV-1-infected subjects. Incubation of mononuclear cells with stimulatory CpG ODN induced CD86 and CD69 up-regulation to a similar degree on innate cells from the three study groups. CpG ODN-stimulated secretion of cytokines was also similar between ESN and controls, while secretion of IFN-alpha was significantly decreased in HIV-1+ individuals. Importantly, expression of IFN-gamma by PMA/Ionomycin-activated CD56(bright) NK cells and CD3+/CD56+ cells was significantly higher in ESN when compared with controls. The anti-viral effects of IFN-gamma are well established, and so our results suggest that IFN-gamma production by innate immune cells might be one of the multiple factors involved in controlling the establishment of sexually transmitted HIV-1 infection.
机译：尚未完全了解控制HIV-1感染建立的机制。特别是，连续暴露于HIV-1但保持血清阴性（ESN）的个体所表现出的先天免疫在自然抵抗中的作用尚未得到充分评估。我们确定了ESN，慢性HIV-1感染和低危HIV-1血清阴性的外周血先天免疫细胞（浆细胞样和髓样树突状细胞，单核细胞，NK细胞，CD3 + / CD56 +细胞和不变的NKT细胞）的频率和功能个人。与对照组相比，ESN证明了先天免疫细胞的频率相似，与HIV-1感染的受试者相比，树突状细胞，NK和不变NKT细胞的频率更高。用刺激性CpG ODN孵育单核细胞可在三个研究组的先天细胞上诱导CD86和CD69上调至相似程度。 ESN和对照组之间，CpG ODN刺激的细胞因子分泌也相似，而HIV-1 +个体的IFN-α分泌却明显减少。重要的是，与对照组相比，ESN中PMA /依诺霉素激活的CD56（亮）NK细胞和CD3 + / CD56 +细胞的IFN-γ表达明显更高。 IFN-γ的抗病毒作用已经确立，因此我们的结果表明，先天免疫细胞产生IFN-γ可能是控制性传播HIV-1感染建立的多种因素之一。

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