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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Aberrant sialylation of serum IgA1 was associated with prognosis of patients with IgA nephropathy.
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Aberrant sialylation of serum IgA1 was associated with prognosis of patients with IgA nephropathy.

机译：血清IgA1的唾液酸化异常与IgA肾病患者的预后有关。

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摘要

Aberrant glycosylation of serum IgA1 was considered as an initial event and involvement in the pathogenesis of IgAN. We previously demonstrated that aberrant glycosylation of serum IgA1 was associated with pathologic phenotype of IgAN. The present study is to investigate if abnormal sialylation of IgA1 affects renal survival of IgAN. 127 patients with biopsy-proven IgAN were enrolled and followed up to 8 years. Seventy-nine healthy and 75 patients with non-IgAN renal diseases were selected as controls. Alpha 2, 6 sialic acid (SA) of serum IgA1 was measured by sandwich-ELISA. Renal survival rate was estimated by Kaplan-Meier method. Alpha 2, 6 SA level in patients with IgAN was lower than that in healthy controls (0.92+/-0.14 vs. 0.98+/-0.12, P=0.001) and non-IgAN glomerulonephritis (0.92+/-0.14 vs. 1.00+/-0.18, n=53, P=0.001). Patients with IgAN in Low SA Group were no significant differences compared with patients in Normal SA Group in age, gender, hypertension, serum creatinine, and excretion of proteinuria. Renal cumulative survival rate was 53.3% in patients in Low SA Group and 83.5% in Normal SA Group (P=0.0008). The lower the alpha 2, 6 SA level of serum IgA1 in patients with IgAN was, the worse their renal survival rate was. Although patients in Low SA Group had worse renal function evaluated by eGFR, there was no significant difference in various CKD stages in non-IgAN renal function controls (n=42, P=0.352). Alpha 2, 6 SA level of serum IgA1 was associated with the prognosis of patients with IgAN and could serve as a predictor of poor prognosis in IgAN.
机译：血清IgA1糖基化异常被认为是初始事件，并且参与了IgAN的发病机制。我们以前证明血清IgA1糖基化异常与IgAN的病理表型有关。本研究旨在调查IgA1的唾液酸化异常是否会影响IgAN的肾脏存活率。 127例经活检证实为IgAN的患者入选，并随访8年。选择79例健康人和75例非IgAN肾病患者作为对照。通过夹心ELISA测定血清IgA1的α2、6唾液酸（SA）。肾存活率通过Kaplan-Meier方法估计。 IgAN患者的α2、6 SA水平低于健康对照组（0.92 +/- 0.14对0.98 +/- 0.12，P = 0.001）和非IgAN肾小球肾炎（0.92 +/- 0.14对1.00+ /-0.18，n＝53，P＝0.001）。低SA组的IgAN患者与正常SA组的患者在年龄，性别，高血压，血清肌酐和蛋白尿排泄方面无显着差异。低SA组患者的肾脏累积生存率为53.3％，正常SA组为83.5％（P = 0.0008）。 IgAN患者的血清IgA1的alpha 2、6 SA水平越低，其肾存活率越差。虽然低SA组的患者通过eGFR评估的肾功能较差，但在非IgAN肾功能对照的各个CKD分期中均无显着差异（n = 42，P = 0.352）。血清IgA1的Alpha 2、6 SA水平与IgAN患者的预后相关，并可作为IgAN预后不良的预测指标。

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