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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Experimental anti-GBM disease as a tool for studying spontaneous lupus nephritis.
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Experimental anti-GBM disease as a tool for studying spontaneous lupus nephritis.

机译：实验性抗GBM疾病可作为研究自发性狼疮肾炎的工具。

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Lupus nephritis is an immune-mediated disease, where antibodies and T cells both play pathogenic roles. Since spontaneous lupus nephritis in mouse models takes 6-12 months to manifest, there is an urgent need for a mouse model that can be used to delineate the pathogenic processes that lead to immune nephritis, over a quicker time frame. We propose that the experimental anti-glomerular basement membrane (GBM) disease model might be a suitable tool for uncovering some of the molecular steps underlying lupus nephritis. This article reviews the current evidence that supports the use of the experimental anti-GBM nephritis model for studying spontaneous lupus nephritis. Importantly, out of about 25 different molecules that have been specifically examined in the experimental anti-GBM model and also spontaneous lupus nephritis, all influence both diseases concordantly, suggesting that the experimental model might be a useful tool for unraveling the molecular basis of spontaneous lupus nephritis. This has important clinical implications, both from the perspective of genetic susceptibility as well as clinical therapeutics.
机译：狼疮性肾炎是一种免疫介导的疾病，其中抗体和T细胞均起着致病作用。由于小鼠模型中的自发性狼疮肾炎需要6到12个月的时间才能显现，因此迫切需要一种可用于在更快的时间范围内描绘导致免疫性肾炎的致病过程的小鼠模型。我们建议，实验性抗肾小球基底膜（GBM）疾病模型可能是发现一些潜在的狼疮性肾炎分子步骤的合适工具。本文回顾了当前的证据，这些证据支持使用实验性抗GBM肾炎模型来研究自发性狼疮肾炎。重要的是，在实验性抗GBM模型以及自发性狼疮肾炎中经过专门检查的大约25种不同分子中，所有分子均会同时影响这两种疾病，这表明该实验模型可能是阐明自发性狼疮分子基础的有用工具肾炎。从遗传敏感性以及临床治疗的角度来看，这具有重要的临床意义。

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