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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Supplementation with RD antigens enhances the protective efficacy of BCG in tuberculous mice.
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Supplementation with RD antigens enhances the protective efficacy of BCG in tuberculous mice.

机译：补充RD抗原可增强BCG对结核小鼠的保护作用。

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摘要

Different combinations of ESAT-6, CFP-10, CFP-21, MPT-64, encoded by RD1 and RD2 of Mycobacterium tuberculosis were evaluated on the basis of antigenicity in PPD positive TB contacts and immunogenicity in C57BL/6J mice immunized with the combination of all four RD antigens. The peripheral blood mononuclear cells of TB contacts showed maximum recognition in response to the combination of ESAT-6+MPT-64 in terms of predominant lymphoproliferation, IFN-gamma levels and the number of responders. On the contrary, the combination of ESAT-6+CFP-21+MPT-64 was found to be most immunogenic based on both T-cell and antibody responses in immunized mice. Prophylactic potential of the selected combinations was assessed as supplementation vaccines to BCG against intravenous challenge with M. tuberculosis in mice. BCG supplementation with the selected combinations resulted in significantly greater protection as compared to BCG alone against experimental tuberculosis and thus appears to be a promising approach to enhance the protective efficacy of the existing vaccine.
机译：根据PPD阳性TB接触者的抗原性和以该组合免疫的C57BL / 6J小鼠的免疫原性，评估了结核分枝杆菌RD1和RD2编码的ESAT-6，CFP-10，CFP-21，MPT-64的不同组合所有四种RD抗原中在主要的淋巴增生，IFN-γ水平和反应者数量方面，对ESAT-6 + MPT-64的结合，TB接触者的外周血单核细胞显示出最大的识别能力。相反，基于免疫细胞中的T细胞和抗体反应，发现ESAT-6 + CFP-21 + MPT-64的组合具有最高的免疫原性。评价所选组合的预防潜力，作为针对小鼠结核分枝杆菌静脉内攻击的BCG补充疫苗。与单独的BCG相比，添加所选组合的BCG导致对实验性肺结核的保护作用明显增强，因此似乎是一种增强现有疫苗保护功效的有前途的方法。

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