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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Analyses of immunosenescent markers in patients with autoimmune disease.
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Analyses of immunosenescent markers in patients with autoimmune disease.

机译：自身免疫性疾病患者的免疫衰老标记分析。

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The objective of this study was to evaluate the degree of immunosenescence in patients with autoimmune disease. T cell receptor excision circles (TREC) and the percentage of CD4+CD28null T cells were studied as markers of immunosenescence in 175 patients with chronic autoimmune arthritis, other connective tissue autoimmune diseases, multiple sclerosis and 60 healthy controls. In both the rheumatoid arthritis (RA) and multiple sclerosis patient group, TREC numbers were age-inappropriately declined which points to an accelerated thymic output. Furthermore, enhanced percentages of CD4+CD28null T cells could be detected in a significant proportion of patients included in this study. These immunosenescent phenomena seemed to be present already early in the disease process. High percentages of CD4+CD28null T cells were associated with the presence of RA linked HLA DR4 alleles and with plasma reactivity to cytomegalovirus. Further analysis of CD4+CD28null T cells provided indications for a restricted T cell receptor (TCR) BV gene expression and cytoplasmic stores of various cytotoxic molecules. This study indicates that the immune system of patients with autoimmune diseases shows signs of an accelerated aging. Both genetic factors, such as HLA DR4, and environmental factors, like CMV infection, might speed up this immunosenescence and contribute in this way to disease pathogenesis.
机译：这项研究的目的是评估自身免疫性疾病患者的免疫衰老程度。研究了175例慢性自身免疫性关节炎，其他结缔组织自身免疫性疾病，多发性硬化症和60例健康对照者的T细胞受体切除环（TREC）和CD4 + CD28null T细胞百分比作为免疫衰老的标志。在类风湿关节炎（RA）和多发性硬化症患者组中，TREC的数量均随着年龄的增长而下降，这表明胸腺输出加快。此外，在这项研究中包括的很大一部分患者中，可以检测到CD4 + CD28null T细胞的百分比提高。这些免疫衰老现象似乎已经在疾病过程的早期出现。高百分比的CD4 + CD28null T细胞与RA连接的HLA DR4等位基因的存在以及与巨细胞病毒的血浆反应性有关。 CD4 + CD28null T细胞的进一步分析为各种细胞毒性分子的限制性T细胞受体（TCR）BV基因表达和细胞质存储提供了指示。这项研究表明，自身免疫性疾病患者的免疫系统显示出加速衰老的迹象。遗传因素（例如HLA DR4）和环境因素（例如CMV感染）都可能加速这种免疫衰老，并以此方式促进疾病的发病。

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