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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Decrease of CD4(+)CD25(high)Foxp3(+) regulatory T cells and elevation of CD19(+)BAFF-R(+) B cells and soluble ICAM-1 in myasthenia gravis.
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Decrease of CD4(+)CD25(high)Foxp3(+) regulatory T cells and elevation of CD19(+)BAFF-R(+) B cells and soluble ICAM-1 in myasthenia gravis.

机译：重症肌无力患者CD4（+）CD25（高）Foxp3（+）调节性T细胞减少，CD19（+）BAFF-R（+）B细胞和可溶性ICAM-1升高。

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Myasthenia gravis (MG) is caused by T-cell-dependent autoantibodies against muscle acetylcholine receptors (AChR) at the neuromuscular junction. Here, we adopted ELISA and flow cytometry techniques to measure the levels of Th1, Th2, Th3 cytokines, inflammatory cytokine and chemokine sICAM-1 and to analyze the phenotypes of CD4(+) and CD8(+) regulatory cells as well as the expression of BAFF-R on CD19(+) B cells in peripheral blood from 75 MG patients and 50 healthy controls. There were no differences in the levels of IL-2, IL-4, IL-10, IL-13, IFN-gamma, TNF-alpha, TGF-beta and sCTLA-4 in both sera and culture supernatants between MG patients and healthy controls. The level of IL-12 was decreased in culture supernatants from MG patients, and the level of sICAM-1 was increased in both sera and culture supernatants from MG patients. Although the populations of CD8(+)CD28(-) and CD8(+)CD122(+) regulatory T cells were not different between MG patients and healthy controls, MG patients exhibited the decreaseof CD4(+)CD25(high)Foxp3(+) regulatory T cells and the increase of CD19(+)BAFF-R(+) B cells, revealing that MG patients should display the dysfunction of T cell balance and the activation of B cell maturation.
机译：重症肌无力（MG）是由针对神经肌肉接头处的肌肉乙酰胆碱受体（AChR）的T细胞依赖性自身抗体引起的。在这里，我们采用ELISA和流式细胞仪技术来测量Th1，Th2，Th3细胞因子，炎性细胞因子和趋化因子sICAM-1的水平，并分析CD4（+）和CD8（+）调节细胞的表型以及表达BAFF-R对75例MG患者和50例健康对照者外周血CD19（+）B细胞的影响。 MG患者和健康人血清和培养上清液中IL-2，IL-4，IL-10，IL-13，IFN-γ，TNF-α，TGF-β和sCTLA-4的水平无差异控件。 MG患者的培养上清液中IL-12水平降低，而MG患者的血清和培养上清液中sICAM-1水平均升高。尽管MG患者和健康对照组之间CD8（+）CD28（-）和CD8（+）CD122（+）调节性T细胞的数量没有差异，但MG患者的CD4（+）CD25（高）Foxp3（+）减少）调节性T细胞和CD19（+）BAFF-R（+）B细胞的增加，表明MG患者应显示T细胞平衡功能障碍和B细胞成熟激活。

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