Gene expression of the constant region of the heavy chain of immunoglobulin G (IgG CRHC) is down-regulated in human decidua in association with preeclampsia.

Freed KA; Brennecke SP; Moses EK

首页> 外文期刊>Journal of Reproductive Immunology >Gene expression of the constant region of the heavy chain of immunoglobulin G (IgG CRHC) is down-regulated in human decidua in association with preeclampsia.

【24h】

Gene expression of the constant region of the heavy chain of immunoglobulin G (IgG CRHC) is down-regulated in human decidua in association with preeclampsia.

机译：与子痫前期相关的人蜕膜中免疫球蛋白G（IgG CRHC）重链恒定区的基因表达下调。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

An aberrant interaction at the maternal/fetal interface between the genetically distinct fetal trophoblast cells and cells of the maternal decidua has been proposed as an initiating factor in one of the major complications of human pregnancy, preeclampsia. Biochemical and epidemiological studies suggest that the immune system plays an important role in preeclampsia. Thus, the aim of this study was to determine the decidual gene expression status in preeclampsia of one of the key components of the adaptive immune system. Total RNA was extracted from decidua collected from women with normal pregnancies and those complicated by preeclampsia. Reverse Northern analysis was performed on 72 cDNAs from human decidua and differentially expressed genes identified were analysed further using semi-quantitative RT-PCR and Northern blot analysis. Expression of the gene encoding the constant region of the heavy chain of immunoglobulin G (IgG CRHC) was shown to be down-regulated in association with preeclampsia. These data support the hypothesis that immune maladaptation may play an important role in the pathogenesis of preeclampsia.

机译：已经提出遗传上不同的胎儿滋养层细胞与母体蜕膜细胞之间在母体/胎儿界面的异常相互作用是人类妊娠的主要并发症之一先兆子痫的起始因素。生化和流行病学研究表明，免疫系统在先兆子痫中起重要作用。因此，本研究的目的是确定先兆子痫中适应性免疫系统关键成分之一的蜕膜基因表达状态。从正常孕妇和先兆子痫孕妇的蜕膜中提取总RNA。对来自人类蜕膜的72个cDNA进行反向Northern分析，并使用半定量RT-PCR和Northern blot分析进一步分析鉴定出的差异表达基因。与子痫前期相关，编码免疫球蛋白G（IgG CRHC）重链恒定区的基因表达被下调。这些数据支持免疫不适应症可能在先兆子痫的发病机理中起重要作用的假设。

著录项

来源
《Journal of Reproductive Immunology》 |2005年第2期|共16页
作者
Freed KA; Brennecke SP; Moses EK;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类基础医学;
关键词
Decidua; Down-Regulation; Immunoglobulin G; Immunoglobulin gamma-Chains; 蜕膜; 先兆子痫;

机译：Decidua;Down-Regulation;Immunoglobulin G;Immunoglobulin gamma-Chains;蜕膜;先兆子痫;

相似文献

外文文献
中文文献
专利

1. Gene expression of the constant region of the heavy chain of immunoglobulin G (IgG CRHC) is down-regulated in human decidua in association with preeclampsia. [J] . Freed KA, Brennecke SP, Moses EK Journal of Reproductive Immunology . 2005,第1a2期

机译：与子痫前期相关的人蜕膜中免疫球蛋白G（IgG CRHC）重链恒定区的基因表达下调。
2. Human immunoglobulin constant heavy G chain (IGHG) (Fcgamma) (GM) genes, defining innate variants of IgG molecules and B cells, have impact on disease and therapy [J] . Vivi-Anne Oxelius, Janardan P. Pey Clinical immunology: The official journal of the Clinical Immunology Society . 2013,第3aPta2期

机译：人免疫球蛋白恒定重链（IGHG）（Fcgamma）（GM）基因定义了IgG分子和B细胞的先天变异体，对疾病和治疗有影响
3. Sequence of a human immunoglobulin gamma 3 heavy chain constant region gene: comparison with the other human Cγ genes [J] . D.H. Crawford, G. Lefranc, M.-P. Lefranc, Nucleic acids research . 1986,第4期

机译：人类免疫球蛋白γ3重链恒定区基因的序列：与其他人类Cγ基因的比较
4. Overexpression and Unique Rearrangement of VH2Transcripts in Immunoglobulin Variable Heavy ChainGenes in Ankylosing Spondylitis Patients [C] . Yeon Joo Kim, Nayoung Kim, Min-Kyung Lee, EU-Korea Conference on Science and Technology . 2011

机译：在强调脊柱胸腺炎患者中免疫球蛋白可变重的vh2transcript的过度表达和独特重新排列
5. The expression of immunoglobulin heavy chain variable region genes in rabbit [D] . DiPietro, Luisa Ann 1989

机译：免疫球蛋白重链可变区基因在兔中的表达
6. Sequence of a human immunoglobulin gamma 3 heavy chain constant region gene: comparison with the other human C gamma genes. [O] . S Huck, P Fort, D H Crawford, 1986

机译：人类免疫球蛋白γ3重链恒定区基因的序列：与其他人类Cγ基因的比较。
7. Human immunoglobulin constant heavy G chain (IGHG) (Fcγ) (GM) genes, defining innate variants of IgG molecules and B cells, have impact on disease and therapy. [O] . Oxelius, Vivi-Anne, Pandey, Janardan P 2013

机译：人免疫球蛋白恒定重链G（IGHG）（Fcγ）（Gm）基因，定义IgG分子和B细胞的先天变体，对疾病和治疗有影响。

Gene expression of the constant region of the heavy chain of immunoglobulin G (IgG CRHC) is down-regulated in human decidua in association with preeclampsia.

摘要

著录项

相似文献

相关主题

期刊订阅