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首页> 外文期刊>Journal of Reproductive Immunology >Skin test reactivity to female sex hormones in women with primary unexplained recurrent pregnancy loss
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Skin test reactivity to female sex hormones in women with primary unexplained recurrent pregnancy loss

机译：患有原发性原因不明的反复性流产的女性的皮肤测试对女性性激素的反应性

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The objective was to examine the hypothesis that primary unexplained recurrent pregnancy loss might be associated with an inappropriate immunologically mediated response to progesterone and/or estrogen. This prospective study included 47 women with two or more documented consecutive early pregnancy losses of unknown etiology, and no previous history of deliveries. Intradermal skin testing was performed in the luteal phase of the cycle (days 16-20) using estradiol benzoate, progesterone, and a placebo of refined sesame oil. Immediate (20. min) and late (24. h and 1 week) skin test readings for all cases were compared with those of 12 parous women of comparable age with no history of spontaneous miscarriages, premenstrual disorders, pregnancy, or sex hormone-related allergic or autoimmune diseases. Main outcome measure was skin test reactivity to estradiol and/or progesterone. Immediate skin test reactivity to both hormones was observed among half of the cases at 20. min. A papule after 24. h, which persisted for up to 1 week, was observed among 32 (68.1%) and 34 (72.3%) cases at the sites of estrogen and progesterone injection, respectively. 55.3% of cases had combined skin test reactivity to both estradiol and progesterone at 1 week. All women in the control group showed absence of skin test reactivity for both estradiol and progesterone at 20. min, 24. h, and 1 week. None of the subjects in either group showed skin test reactivity to placebo. There is an association between primary unexplained recurrent pregnancy loss and skin test reactivity to female sex hormones.
机译：目的是检验以下假设，即原发性无法解释的反复妊娠丢失可能与对孕激素和/或雌激素的免疫学介导的反应不当有关。这项前瞻性研究纳入了47名妇女，她们有两个或两个以上连续病因不明的连续早孕记录，并且没有分娩史。在周期的黄体期（第16至20天）使用雌二醇苯甲酸酯，孕酮和精制芝麻油安慰剂进行皮内皮肤测试。将所有病例的即刻（20分钟）和晚（24.h和1周）皮肤测试读数与12例年龄相似，无自然流产，经前疾病，妊娠或性激素相关史的产妇进行比较。过敏性或自身免疫性疾病。主要结局指标是皮肤测试对雌二醇和/或孕酮的反应性。在20分钟后的一半病例中，观察到对两种激素的立即皮肤测试反应性。在雌激素和孕激素注射部位分别观察到32例（68.1％）和34例（72.3％）病例在24 h后持续1周的丘疹。 15.3周时，有55.3％的患者对雌二醇和孕酮的皮肤测试反应性综合。对照组中的所有妇女在20分钟，24小时和1周时均未表现出对雌二醇和孕酮的皮肤测试反应性。两组中的受试者均未显示对安慰剂的皮肤测试反应性。原发性无法解释的反复妊娠丢失与皮肤测试对女性性激素的反应性之间存在关联。

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