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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Prognostic significance of circulating IL-10 and IL-6 serum levels in colon cancer patients undergoing surgery.
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Prognostic significance of circulating IL-10 and IL-6 serum levels in colon cancer patients undergoing surgery.

机译：结肠癌患者手术中循环IL-10和IL-6血清水平的预后意义。

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The prognostic significance of IL-10 and IL-6 serum levels in colon cancer patients undergoing surgery was investigated. To this end, 50 candidate patients with colon cancer for surgery were admitted to the study. Of these, 30 could be subjected to a potentially curative surgery. Cytokine serum levels at several time points before and after surgery were measured by ELISA. Circulating levels of IL-10 and IL-6 were found to be elevated in cancer patients with respect to controls. Both IL-10 and IL-6 serum levels were demonstrated to predict the likelihood of curative surgery (predictive accuracy, 83.3%). IL-10 serum levels returned to normal in all but 6 patients who underwent curative surgery. These latter had tumor recurrence (predictive accuracy, 100%). In contrast, IL-6 serum levels significantly decreased in all patients, regardless of whether cure was surgically achieved, but did not normalize. On multivariate analysis, basal IL-10 serum levels were found to be among the variables significantly predicting the disease-free survival rate. Stepwise regression selected tumor stage, basal IL-10 serum level, and basal CEA serum level as the best combination of variables for prediction of the likelihood of tumor recurrence. In conclusion, preoperative serum levels of IL-10 were shown to be useful markers for predicting both likelihood to perform curative surgery and, in combination with the 16th postoperative day IL-10 serum levels, tumor recurrence (predictive accuracy, 73.6 and 96%, respectively). IL-6 serum levels were found to have a more limited prognostic role. Copyright 2001 Elsevier Science (USA).
机译：研究了IL-10和IL-6血清水平在结肠癌手术患者中的预后意义。为此，该研究接纳了50名结肠癌手术患者。其中，有30例可能会接受根治性手术。通过ELISA测量手术前后几个时间点的细胞因子血清水平。发现相对于对照，癌症患者中IL-10和IL-6的循环水平升高。已证明IL-10和IL-6血清水平均可预测治愈性手术的可能性（预测准确性为83.3％）。除6例接受根治性手术的患者外，其余所有患者的IL-10血清水平均恢复正常。后者具有肿瘤复发（预测准确性，100％）。相反，无论是否通过手术治愈，但所有患者的IL-6血清水平均显着降低，但并未正常化。在多变量分析中，发现基础IL-10血清水平是显着预测无病生存率的变量之一。逐步回归选择肿瘤分期，基础IL-10血清水平和基础CEA血清水平作为预测肿瘤复发可能性的变量的最佳组合。总之，术前血清IL-10水平被证明是预测进行根治性手术的可能性的有用标志物，结合术后16天的IL-10血清水平，肿瘤复发（预测准确率分别为73.6和96％，分别）。发现IL-6血清水平具有更有限的预后作用。版权所有2001 Elsevier Science（美国）。

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