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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Executive function and diffusion in frontal white matter of adults with moyamoya disease
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Executive function and diffusion in frontal white matter of adults with moyamoya disease

机译：成人烟雾病患者额叶白质的执行功能和扩散

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摘要

Background: Cognitive impairment is a frequent complication of moyamoya disease (MMD) in adults. Chronic hypoperfusion in frontal lobes can lead to subtle brain injury, resulting in cognitive dysfunctions. Apparent diffusion coefficient (ADC) in normal-appearing white matter on conventional magnetic resonance imaging correlates with cerebral hemodynamics in the frontal lobe. Objective: The purpose of this study was to examine the relationship of ADC with executive function in patients with MMD. Methods: Thirty-one patients (25 women and 6 men; mean age, 32.6 ± 10.4 years) were included in this study. Executive function was evaluated by the Frontal Assessment Battery (FAB) at 21.5 ± 7.5 years after disease onset. ADC was measured in the normal-appearing frontal white matter. Results: ADC was statistically related to the occurrence of executive dysfunction in multivariate analysis (P =.0179). Total FAB score and ADC were negatively correlated (r2 =.22; P =.0072; Spearman correlation coefficient, -.41; P =.024). Elevated ADC predicted executive dysfunction (area under the receiver operating characteristic curve,.73; 95% confidence interval,.55-.91; P =.029). Conclusions: The association of ADC with executive function might suggest that ADC is useful in screening for executive dysfunction during follow-up in the outpatient setting.
机译：背景：认知障碍是成年人烟雾病（MMD）的常见并发症。额叶的慢性灌注不足可导致细微的脑损伤，从而导致认知功能障碍。传统磁共振成像中正常出现的白质中的表观扩散系数（ADC）与额叶的脑血流动力学相关。目的：本研究旨在探讨MMD患者ADC与执行功能的关系。方法：本研究纳入了31名患者（25名女性和6名男性;平均年龄32.6±10.4岁）。疾病发作后21.5±7.5年，通过额叶评估组（FAB）评估执行功能。 ADC是在正常出现的额叶白质中测量的。结果：在多变量分析中，ADC与执行功能障碍的发生在统计学上相关（P = .0179）。 FAB总得分与ADC呈负相关（r2 = .22; P = .0072; Spearman相关系数，-.41; P = .024）。 ADC预测的执行功能障碍升高（接收器工作特性曲线下的面积，.73; 95％置信区间，.55-.91; P = .029）。结论：ADC与执行功能的关联可能表明ADC可用于门诊随访期间筛查执行功能障碍。

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