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首页> 外文期刊>Journal of studies on alcohol >Memory and perseveration on a win-stay, lose-shift task in rats exposed neonatally to alcohol.
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Memory and perseveration on a win-stay, lose-shift task in rats exposed neonatally to alcohol.

机译：新生暴露于酒精的大鼠在坚持，输班的过程中的记忆力和坚持不懈。

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OBJECTIVE: It is important to understand the relationship between perseverative responding resulting from perinatal exposure to alcohol and potential underlying causes, including attention, memory, or response-inhibition problems. The present study was designed to examine the relationship between perseveration and memory. METHOD: Rats exposed neonatally to 6 g/kg/day alcohol from postnatal day (PD) 4 through PD 9 using an artificial rearing technique (n = 8) were compared with an artificially reared gastrostomy control group (n = 8) and a suckle control group (n = 8). Activity levels were assessed from PD 18-21. Beginning on PD 45, subjects were deprived of food and responded for food on a two-lever win-stay, lose-shift task in which reinforcement probability was a function of reinforcement delivery on the previous trial. If reinforcement was delivered, only a response on the same lever (stay) was reinforced. If reinforcement was not delivered, only a response on the opposite lever (shift) was reinforced. Effective responding depended on subjects remembering whether a reinforcer was delivered on the preceding trial. The intertrial interval varied across conditions (5 seconds or 60 seconds). RESULTS: Alcohol-exposed rats showed increased activity during activity testing but did not differ from controls on win-stay, lose-shift accuracy. All groups showed a performance decrease at longer intertrial intervals. Alcohol-exposed rats showed increased lever pressing during the intertrial interval compared with suckle control rats but not with gastrostomy control rats. CONCLUSIONS: Choice behavior was comparable for all groups on the win-stay, lose-shift task, indicating that memory, as assessed by this task, was not differentially affected by alcohol exposure. Alcohol-exposed rats responded more during the intertrial interval compared with suckle controls, suggesting increased activity without increased response inhibition. The win-stay, lose-shift procedure is a potentially useful tool for separating simple activity level effects, memory-related effects, and response-inhibition effects. This study also highlights the need for additional research describing the relationship between perseverative responding and underlying mechanisms.
机译：目的：了解围产期暴露于酒精引起的持续反应与潜在的潜在原因（包括注意力，记忆力或反应抑制问题）之间的关系非常重要。本研究旨在检查坚持和记忆之间的关系。方法：使用人工饲养技术（n = 8），从出生后第4天到PD 9从新生儿处暴露于6 g / kg / day酒精的大鼠与人工饲养的胃造口术对照组（n = 8）和乳汁进行比较对照组（n = 8）。从PD 18-21评估活动水平。从PD 45开始，受试者被剥夺了食物，并通过两杆制胜负，倒班任务对食物做出反应，其中强化概率是先前试验中强化传递的函数。如果进行了加固，则只会增强对同一杆（保持杆）的响应。如果未提供加固，则仅增强对另一档杆的响应（换档）。有效的响应取决于受试者是否记得在先前的试验中是否使用了加固剂。间隔时间因条件而异（5秒或60秒）。结果：暴露于酒精的大鼠在活动测试期间显示出增加的活动，但与对照组相比，其保持，失步的准确性无差异。所有组在较长的间隔时间内均表现出性能下降。与哺乳期对照大鼠相比，酒精暴露的大鼠在间隔时间显示杠杆增加，而胃造口术对照大鼠则没有。结论：在胜任，输班任务上，所有组的选择行为均具有可比性，表明该任务评估的记忆力不受酒精暴露的影响。与哺乳期对照组相比，暴露于酒精的大鼠在试验间隔期间的反应更多，这表明活性增加而应答抑制作用没有增加。获胜，失败转移程序是一种潜在的有用工具，用于分离简单的活动水平效应，与记忆相关的效应和抑制反应的效应。这项研究还强调了需要进行其他研究来描述持久性反应与潜在机制之间的关系。

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