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首页> 外文期刊>Journal of the American Academy of Child and Adolescent Psychiatry >White matter hyperintensities and their associations with suicidality in psychiatrically hospitalized children and adolescents.
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White matter hyperintensities and their associations with suicidality in psychiatrically hospitalized children and adolescents.

机译：在精神病院住院的儿童和青少年中，白质过高及其与自杀的关系。

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OBJECTIVE:: Increasingly, researchers and clinicians are recognizing that there may be biological markers associated with increased risk of suicide. The objective of this study was to compare white matter hyperintensities in psychiatrically hospitalized children and youth with and without a history of suicide attempt while controlling for other variables. METHOD:: White matter hyperintensities of 153 child and adolescent psychiatry inpatients were rated on T2-weighted magnetic resonance imaging scans using a modified Coffey scale. DSM-IV diagnosis, history of suicide attempt, and control variables such as gender, age, comorbid medical illnesses, developmental disorder, substance abuse, severity of mental illness, head injury, and possible cerebral hypoxia were obtained from discharge medical records. RESULTS:: Within the unipolar depression group (n = 48), white matter hyperintensities were significantly associated with a higher prevalence of past suicide attempts (Fisher exact test, p =.03). Logistic regression analysis confirmed this relationship, indicating that none of the control variables confounded our results and suggesting a specificity of 0.94. CONCLUSIONS:: This is the first report of an increased prevalence of white matter hyperintensities in children and youth with unipolar depression and a history of suicide attempt. Replication and expansion of our preliminary findings could be of great clinical interest.
机译：目的：：越来越多的研究人员和临床医生认识到可能存在与自杀风险增加相关的生物学标记。这项研究的目的是在控制其他变量的同时，比较有或没有自杀未遂史的，在精神病院住院的儿童和青少年中的白质高信号。方法：对153名儿童和青少年精神病患者的白质高强度进行了T2加权磁共振成像扫描，并使用了改良的科菲量表。从出院医疗记录中获得了DSM-IV诊断，自杀未遂史以及控制变量，例如性别，年龄，合并疾病，发育障碍，药物滥用，精神疾病的严重程度，头部受伤以及可能的脑缺氧。结果：在单相抑郁症组（n = 48）内，白质高信号与过去自杀未遂的发生率显着相关（Fisher精确检验，p = .03）。 Logistic回归分析证实了这种关系，表明没有任何控制变量会混淆我们的结果，并表明特异性为0.94。结论：：这是关于单极性抑郁症和自杀未遂的儿童和青年中白质高信号患病率上升的第一份报告。复制和扩展我们的初步发现可能具有重大的临床意义。

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