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首页> 外文期刊>Journal of the Neurological Sciences: Official Bulletin of the World Federation of Neurology >Assessment of structural and functIonal vIsual outcomes in relapsIng remIttIng multIple sclerosIs with vIsual evoked potentIals and optIcal coherence tomography
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Assessment of structural and functIonal vIsual outcomes in relapsIng remIttIng multIple sclerosIs with vIsual evoked potentIals and optIcal coherence tomography

机译：用视觉诱发电位和光学相干断层扫描技术评估复发性多发性巩膜的结构和功能性视觉结局

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The purpose of this study is to consider the clinical utility of optical coherence tomography (OCT) and find a correlation with VEP. Effects of different disease modifying treatments (DMT) were further evaluated by measuring OCT parameters and whether a correlation exists between the RNFL thickness, disease duration and expanded disability status scale (EDSS) were also assessed. 13 patients were on interferon beta-1a (IFN), 14 patients were receiving glatiramer acetate (GA), 19 patients were not being treated with any DMT and 21 healthy controls were included the study. During OCT examination, retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) thickness was found to be lower in all MS groups but macular volume (MV) was lower only in GA group than controls. Although, P100 latencies were longer than controls in all MS groups, there was no statistically significant difference between IFN and w/o DMT groups. Patients with ON history, P100 latencies were found significantly longer than those without ON. VEP amplitudes were found lower with ON history patients than those without ON, however this was not statistically significant. EDSS strongly correlated with P100 latency, RNLF, GCC but no correlation was observed with VEP amplitude and MV. Our results show that RNFL, GCC and MV were all decreased in MS patients with or without DMT comparing to controls and it is more prominent in eyes with ON. Further follow-up studies are warranted to understand the pathophysiology of CNS axonal degeneration and involvement of optic nerves.
机译：这项研究的目的是考虑光学相干断层扫描（OCT）的临床实用性，并找到与VEP的相关性。通过测量OCT参数进一步评估了不同疾病改良治疗（DMT）的效果，并且还评估了RNFL厚度，疾病持续时间和扩大残疾状况量表（EDSS）之间是否存在相关性。 13例患者接受干扰素β-1a（IFN）治疗，14例患者接受醋酸格拉替雷（GA），19例患者未接受任何DMT治疗，包括21名健康对照。在OCT检查期间，发现所有MS组的视网膜神经纤维层（RNFL）和神经节细胞复合物（GCC）厚度均较低，但仅GA组的黄斑体积（MV）低于对照组。尽管在所有MS组中P100潜伏期都比对照组长，但IFN和无WMT组之间在统计学上没有显着差异。有ON史的患者，发现P100潜伏期明显长于没有ON史的患者。发现有ON史的患者的VEP幅度比没有ON史的患者低，但这在统计学上无统计学意义。 EDSS与P100潜伏期，RNLF，GCC密切相关，但与VEP振幅和MV无相关性。我们的结果显示，与对照组相比，有或没有DMT的MS患者的RNFL，GCC和MV均降低，而在有ON的眼中则更为明显。有必要进行进一步的随访研究，以了解中枢神经系统轴突变性和视神经受累的病理生理学。

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