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首页> 外文期刊>Journal of Theoretical Biology >Innovation in gene regulation: the case of chromatin computation.
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Innovation in gene regulation: the case of chromatin computation.

机译：基因调控方面的创新：染色质计算的案例。

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Chromatin regulation is understood to be one of the fundamental modes of gene regulation in eukaryotic cells. We argue that the basic proteins that determine the chromatin architecture constitute an evolutionary ancient layer of transcriptional regulation common to all three domains of life. We explore phylogenetically, sources of innovation in chromatin regulation, focusing on protein domains related to chromatin structure and function, demonstrating a step-wise increase of complexity in chromatin regulation. Building upon the highly conserved use of variants of chromosomal architectural proteins to distinguish chromosomal states, Eukarya secondarily acquired mechanisms for writing signals. The acquisition of reader domains enabled decoding of these complex, signal combinations and a decoupling of the signal from immediate biochemical effects. We show how the coupling of reading and writing, which is most prevalent in crown-group Eukarya, could have converted chromatin into a powerful computational device capable of storing and processing more information than pure cis-regulatory networks.
机译：染色质调节被认为是真核细胞中基因调节的基本模式之一。我们认为，决定染色质结构的基本蛋白质构成了生命的所有三个域共同的转录调控的进化古老层。我们在系统发育上探索染色质调控的创新来源，重点研究与染色质结构和功能相关的蛋白质域，证明了染色质调控的复杂性逐步提高。在高度保守地使用染色体建筑蛋白变异体来区分染色体状态的基础上，Eukarya其次获得了写入信号的机制。读取器域的获得使这些复杂的信号组合得以解码，并使信号与直接生化作用脱钩。我们展示了如何在冠群Eukarya中最常见的读写耦合将染色质转换为功能强大的计算设备，该设备能够存储和处理比纯顺式调控网络更多的信息。

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