Motor Neuron Disease and Trace Element Toxicity

Michaei J. Strong; Beiping He

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Motor Neuron Disease and Trace Element Toxicity

机译：运动神经元疾病和微量元素毒性

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There is a significant degree of overlap between the clinical syndromes of amyotrophic lateral sclerosis (ALS) and chronic A1C1-3 neurotoxicity. Although there is little, if any, significant overlap with acute A1C1-3 neurotoxicity, these latter studies are of importance in demonstrating that an exogenously administered neurotoxin can induce a posttranslational modification in neurofilament, sufficient to bring about neurofilamentous inclusions. The value in the study of chronic A1C1-3 neurotoxicity is in the recapitulation of neuronal damage resembling that of ALS and the observations that suggest that the potential for recovery from the neuronal injury can be mediated by microglia. Studies are currently in progress to further define this potential,

机译：肌萎缩性侧索硬化症（ALS）的临床综合征与慢性A1C1-3神经毒性之间存在显着程度的重叠。尽管与急性A1C1-3神经毒性几乎没有（如果有）显着重叠，但这些后期研究对证明外源施用的神经毒素可以诱导神经丝的翻译后修饰（足以产生神经丝包涵体）非常重要。在慢性A1C1-3神经毒性研究中的价值在于类似于ALS的神经元损伤的概括和观察结果，这些结果表明小胶质细胞可以介导从神经元损伤中恢复的潜力。目前正在进行研究以进一步确定这种潜力，

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《Journal of Trace Elements in Experimental Medicine》 |2000年第1期|共10页
作者
Michaei J. Strong; Beiping He;
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正文语种 eng
中图分类生物化学;
关键词
aluminum; motor neuron disease; neurofilament; neurotoxicity; amyotrophic lateral sclerosis;

机译：铝;运动神经元疾病;神经丝;神经毒性;肌萎缩性侧索硬化;

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1. Motor Neuron Disease and Trace Element Toxicity [J] . Michaei J. Strong, Beiping He Journal of Trace Elements in Experimental Medicine . 2000,第1期

机译：运动神经元疾病和微量元素毒性
2. Trace elements and toxic heavy metals play a role in Buerger's disease and atherosclerotic peripheral arterial occlusive disease. [J] . Fazeli B International angiology: A journal of the International Union of Angiology . 2011,第6期

机译：微量元素和有毒重金属在Buerger病和动脉粥样硬化性外周动脉闭塞性疾病中起作用。
3. Trace elements and toxic heavy metals play a role in Buerger disease and atherosclerotic peripheral arterial occlusive disease. [J] . Arslan C, Altan H, Akgun OO, International angiology: A journal of the International Union of Angiology . 2010,第6期

机译：微量元素和有毒重金属在Buerger病和动脉粥样硬化性外周动脉闭塞性疾病中起作用。
4. SWATH analysis of patient-derived iPSC to motor neurons for the discovery of protein network perturbations that underlie motor neuron diseases [C] . Andrea D. Matlock, Berhan Mandefro, Loren Ornelas, ASMS Conference on Mass Spectrometry and Allied Topics . 2015

机译：对运动神经元的患者衍生的IPSC的SWATH分析，用于发现蛋白质网络扰动的蛋白质网络扰动
5. Non-cell Autonomous Toxicity in Motor Neuron Disease: Evidence and Mechanisms of Astrocyte-Driven Neurotoxicity in FUS-ALS [D] . McAvoy, Kevin James 2019

机译：运动神经元疾病的非细胞自主毒性：FUS-ALS中星形胶质细胞驱动神经毒性的证据和机制
6. Trace elements in the spinal cord and other tissues in motor neuron disease. [O] . J D Mitchell, B W East, I A Harris, 1986

机译：脊髓和运动神经元疾病中其他组织中的微量元素。
7. Trace elements in the spinal cord and other tissues in motor neuron disease. [O] . Mitchell, J D, East, B W, Harris, I A, 1986

机译：脊髓和运动神经元疾病中其他组织中的微量元素。
8. WHO/IAEA Joint Research Programme on Trace Elements in Cardiovascular Diseases. Report of a Consultants' Meeting, Vienna, Austria, 18-19 December 1979 [R] . Junkermann, W. 1980

机译：世卫组织/国际原子能机构关于心血管疾病中微量元素的联合研究计划。顾问会议的报告，1979年12月18日至19日，奥地利维也纳

Motor Neuron Disease and Trace Element Toxicity

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