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首页> 外文期刊>Journal of Veterinary Diagnostic Investigation >Lipid-rich carcinoma in the mammary gland of a Djungarian hamster (phodopus sungorus).
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Lipid-rich carcinoma in the mammary gland of a Djungarian hamster (phodopus sungorus).

机译：Djungarian仓鼠（ phodopus sungorus ）的乳腺中富含脂质的癌。

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摘要

A lipid-rich carcinoma of the mammary gland was diagnosed in a female Djungarian hamster (Phodopus sungorus), which was kept as an indoor pet. The animal underwent surgery for a primary tumor arising in the mammary gland at the age of 16 months, and also for a recurrent tumor 6 months later. Histologically, the primary neoplasm was composed of 2 different cell populations: nonvacuolated glandular neoplastic cells with moderate atypia, and vacuolated neoplastic cells with marked atypia. Transition from the nonvacuolated glandular cells to the vacuolated cells was frequently seen. The recurrent neoplasm was composed predominantly of vacuolated neoplastic cells that often invaded the surrounding soft tissue. The cytoplasmic vacuoles contained neutral lipids, as confirmed by oil red O and Nile blue staining. The vacuolated neoplastic cells were immunopositive for cytokeratin and negative for vimentin, -smooth muscle actin, p63, estrogen receptor, and androgen receptor. Presumably, this high-grade, lipid-rich mammary carcinoma had developed from a low-grade mammary adenocarcinoma.
机译：在一只雌性Djungarian仓鼠（ Phodopus sungorus ）中诊断出富含脂质的乳腺癌，将其作为室内宠物饲养。该动物接受了16个月大时在乳腺中发生的原发性肿瘤的手术，并在6个月后进行了复发性肿瘤的手术。从组织学上讲，原发性肿瘤由2个不同的细胞群组成：具有中度非典型性的非真空腺瘤性肿瘤细胞和具有明显非典型性的空泡性肿瘤细胞。从非真空化的腺细胞向空泡化的细胞的转变是常见的。复发性肿瘤主要由空泡的赘生性细胞组成，其通常会侵犯周围的软组织。细胞质液泡含有中性脂质，如油红O和尼罗蓝染色所证实。空化的赘生性细胞的细胞角蛋白免疫阳性，而波形蛋白，-平滑肌肌动蛋白，p63，雌激素受体和雄激素受体阴性。据推测，这种高级别，富含脂质的乳癌是从低级别的乳腺癌发展而来的。

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