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首页> 外文期刊>Journal of Surgical Oncology >T-Cell Immunoglobulin Mucin-3 Expression in Bladder Urothelial Carcinoma: Clinicopathologic Correlations and Association With Survival
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T-Cell Immunoglobulin Mucin-3 Expression in Bladder Urothelial Carcinoma: Clinicopathologic Correlations and Association With Survival

机译:膀胱尿路上皮癌中的T细胞免疫球蛋白Mucin-3表达:临床病理相关性和与生存的关联。

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摘要

Background: T cell immunoglobulin mucin-3 (Tim-3) was initially recognized as a pivotal immune checkpoint inhibitor that maintains immune homeostasis and tolerance. Recently, Tim-3 has been demonstrated to play an important role in tumor-associated immune suppression and aberrant Tim-3 expression has been reported in several human malignancies. However, the role of Tim-3 in bladder urothelial carcinoma (BUC) remains largely unknown. The present study aims to investigate Tim-3 expression in BUC and analyze correlations with clinicopathologic outcomes and postoperative survival.
机译:背景:T细胞免疫球蛋白粘蛋白3(Tim-3)最初被认为是维持免疫稳态和耐受性的关键免疫检查点抑制剂。最近,已经证明Tim-3在肿瘤相关的免疫抑制中起重要作用,并且已经报道了Tim-3在几种人类恶性肿瘤中的异常表达。但是,Tim-3在膀胱尿路上皮癌(BUC)中的作用仍然未知。本研究旨在调查Tim-3在BUC中的表达,并分析其与临床病理结果和术后生存的相关性。

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