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首页> 外文期刊>Clinical and Experimental Immunology: An Official Journal of the British Society for Immunology >Peripheral CD4 loss of regulatory T cells is associated with persistent viraemia in chronic HIV infection.
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Peripheral CD4 loss of regulatory T cells is associated with persistent viraemia in chronic HIV infection.

机译：在慢性HIV感染中，调节性T细胞的外周CD4丢失与持续的病毒血症有关。

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Summary Chronic HIV infection is associated with T cell abnormalities and altered effector function. Regulatory T cells (T(reg)) are CD4(+) T cells that play a critical role in regulating the immune system. The impact of regulatory T cells on HIV infection and disease progression may be highly significant. We hypothesize that chronic antigenic stimulation from a persistent, high viraemic state may promote a population of T(reg) that contributes to HIV-associated immune dysfunction. We evaluated the pattern of T(reg) in chronically infected, HIV-positive individuals over a course of 6 months. T(reg) are depleted at a distinct rate from that of absolute CD4 cells and loss of T(reg) is slower in the presence of viral suppression. In vitro depletion of CD25(+) CD4(+) cells resulted in increased Gag-specific CD4 and CD8 responses. A significant correlation between ex vivo measurement of T(reg) and Gag-specific CD4 T cell responses was observed (r = -0.41, P = 0.018) with a trend observed with Gag-specific CD8 T cell responses (P = 0.07). The impact of HIV infection on the T(reg) population directly complicates the measured effect of T(reg) on the immune dysfunction although our data support the important role of T(reg) on modulating the effector T cell response in chronic infection.
机译：总结慢性HIV感染与T细胞异常和效应器功能改变有关。调节性T细胞（T（reg））是CD4（+）T细胞，在调节免疫系统中起关键作用。调节性T细胞对HIV感染和疾病进展的影响可能非常重要。我们假设持续的，高病毒血症状态的慢性抗原刺激可能促进T（reg）的人口，这有助于HIV相关的免疫功能障碍。我们在6个月的过程中评估了慢性感染HIV阳性个体的T（reg）模式。 T（reg）的耗竭速率与绝对CD4细胞的耗竭速率不同，并且在存在病毒抑制作用的情况下，T（reg）的损耗较慢。 CD25（+）CD4（+）细胞的体外耗竭导致Gag特异性CD4和CD8反应增加。观察到T（reg）的离体测量与Gag特异性CD4 T细胞应答之间的显着相关性（r = -0.41，P = 0.018），而Gag特异性CD8 T细胞应答具有趋势（P = 0.07）。尽管我们的数据支持T（reg）在调节慢性感染中效应T细胞反应中的重要作用，但HIV感染对T（reg）人群的影响直接使T（reg）对免疫功能障碍的测定作用复杂化。

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