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Effects of central administration of bisphenol A on behaviors and growth in chicks

机译:集中施用双酚A对雏鸡行为和生长的影响

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摘要

We investigated the central effect of the estrogenic pollutant, bisphenol A (BPA), on behaviors, growth and several organ weights in chicks. Four-day-old male chicks were injected into the brain with BPA at doses of 0, 100, 200 mu g. Food intake andbody weight gain were determined, but no significant effects of BPA were detected. Secondly, behaviors of these chicks were tested under an isolated situation. The behaviors such as frequency of jumping, distress vocalization and duration of crouching were monitored. Central injection of BPA increased distress vocalizations in a dose-dependent manner, though no significant changes were observed in other indices. Thereafter, four organ (testis, kidney, liver and brain) weights were measured. No significant differences in all the organs were detected among all treatments. These results suggest that the accumulation of BPA in the central nervous system may somewhat induce the behavioral change in a stressful situation.
机译:我们调查了雌激素污染物双酚A(BPA)对小鸡的行为,生长和一些器官重量的主要影响。将四天大的雄性小鸡以0、100、200微克的剂量注射到BPA中。确定了食物摄入量和体重增加,但未检测到BPA的显着影响。其次,在孤立的情况下测试了这些小鸡的行为。监测诸如跳跃频率,遇险声音和蹲伏时间等行为。尽管在其他指标上未观察到明显变化,但中央注射双酚A剂量依赖性增加了遇险声音。此后,测量四个器官(睾丸,肾脏,肝脏和大脑)的重量。在所有处理之间,未检测到所有器官的显着差异。这些结果表明,BPA在中枢神经系统中的积累可能会在压力下诱发行为改变。

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