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首页> 外文期刊>感染症学雑誌 >Drug susceptibility and analysis using pulsed-field gel electrophoresis of Streptococcus pyogenes strains isolated from the patients with streptococcal toxic shock syndrome (STSS) in Japan
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Drug susceptibility and analysis using pulsed-field gel electrophoresis of Streptococcus pyogenes strains isolated from the patients with streptococcal toxic shock syndrome (STSS) in Japan

机译：从日本链球菌毒性休克综合征（STSS）患者中分离出的化脓性链球菌菌株的药敏性和脉冲场凝胶电泳分析

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Previously, we have performed T typing of Streptococcus pyogenes strains isolated from patients with streptococcal toxic shock syndrome (STSS) in Japan, and streptococcal pyrogenic exotoxin (SPE) typing for epidemiological examination. In this study, we conducted a drug sensitivity test using these strains, and investigated the results of gene analysis by pulse-field gel electrophoresis (PFGE) of S. pyogenes strains derived from patients with STSS, the patient's family, and patients other than those with STSS. To clarify the relationship between the host and bacterial factors, we investigated the association between clinical symptoms and T typing of the isolated strains/production of streptococcal pyrogenic exotoxin. There were no strains resistant to beta-lactams, and only 1 strain was resistant to multiple agents other than beta-lactams. The PFGE pattern of T1 type strains was classified into 2 ; the pattern was consistent between the strains derived from patients with STSS and those derived from thepatient's family. The PFGE pattern of T3 type strains was classified into 5 (IV) ; Pattern I, which was most frequently observed, was detected in both the strains derived from patients with STSSon-STSS. However, Patterns II and III were detected only in the strains derived from patients with non-STSS. Patterns IV and V were detected only in the strains derived from patients with STSS. When examining the association between clinical symptoms and bacterial factors, disseminated intravascular coagulation (DIC) was associated with T1-SPE B-producing strains, and pharyngitis was associated with T3-SPE A-producing strains. In the future, the relationship between the host and bacterial factors should be further investigated.
机译：以前，我们已经对日本分离自化脓性链球菌中毒性休克综合征（STSS）患者的化脓性链球菌菌株进行了T型分型，并进行了流行病学检查的链球菌热原性外毒素（SPE）分型。在这项研究中，我们对这些菌株进行了药物敏感性测试，并通过脉冲场凝胶电泳（PFGE）研究了来自STSS患者，患者家庭以及其他患者的化脓性链球菌菌株的基因分析结果。与STSS。为了阐明宿主与细菌因素之间的关系，我们调查了临床症状与分离株的T型分型/链球菌热原性外毒素产生之间的关系。没有对β-内酰胺类有抗性的菌株，只有1个菌株对除β-内酰胺类以外的多种药物有抗性。 T1型菌株的PFGE图谱分为2种;在来自STSS患者的菌株与来自患者家庭的菌株之间，模式是一致的。 T3型菌株的PFGE模式分为5（IV）;在源自STSS /非STSS患者的两种菌株中均检测到最常观察到的模式I。但是，仅在非STSS患者的菌株中检测到II型和III型。仅在来自STSS患者的菌株中检测到IV型和V型。在检查临床症状和细菌因素之间的关联时，弥散性血管内凝血（DIC）与产生T1-SPE B的菌株有关，咽炎与产生T3-SPE A的菌株有关。将来，宿主和细菌因素之间的关系应进一步研究。

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