首页> 美国卫生研究院文献>Journal of Genomics >Complete Genome Sequence and Comparative Genomics of a Streptococcus pyogenes emm3 Strain M3-b isolated from a Japanese Patient with Streptococcal Toxic Shock Syndrome
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Complete Genome Sequence and Comparative Genomics of a Streptococcus pyogenes emm3 Strain M3-b isolated from a Japanese Patient with Streptococcal Toxic Shock Syndrome

机译:化脓性链球菌emm3菌株M3-b的完整基因组序列和比较基因组学从日本链球菌毒性休克综合征患者中分离

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摘要

Epidemiologic typing of Streptococcus pyogenes (GAS) is frequently based on the genotype of the emm gene, which encodes M/Emm protein. In this study, the complete genome sequence of GAS emm3 strain M3-b, isolated from a patient with streptococcal toxic shock syndrome (STSS), was determined. This strain exhibited 99% identity with other complete genome sequences of emm3 strains MGAS315, SSI-1, and STAB902. The complete genomes of five additional strains isolated from Japanese patients with and without STSS were also sequences. Maximum-likelihood phylogenetic analysis showed that strains M3-b, M3-e, and SSI-1, all which were isolated from STSS patients, were relatively close.
机译:化脓性链球菌(GAS)的流行病学分型通常基于编码M / Emm蛋白的emm基因的基因型。在这项研究中,确定了从患有链球菌毒性休克综合征(STSS)的患者中分离出的GAS emm3菌株M3-b的完整基因组序列。该菌株与emm3菌株MGAS315,SSI-1和STAB902的其他完整基因组序列具有99%的同一性。从有和没有STSS的日本患者中分离出的五种其他菌株的完整基因组也是序列。最大似然系统发育分析表明,从STSS患者中分离出的菌株M3-b,M3-e和SSI-1相对较近。

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