• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>感染症学雑誌 >Epidemiological study on Streptococcus pyogenes strains isolated from the patients with streptococcal toxic shock syndrome (STSS) in Japan in 1992-2001
【24h】

Epidemiological study on Streptococcus pyogenes strains isolated from the patients with streptococcal toxic shock syndrome (STSS) in Japan in 1992-2001

机译：1992 - 2001年日本中日日患者患有患有链球菌毒性休克综合征（STSS）患者分离的链球菌菌株的流行病学研究

获取原文
获取原文并翻译 | 示例
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

To investigate clinical and microbiological features of streptococcal toxic shock syndrome (STSS), clinical, epidemiological, and bacteriological data obtained from 250 patients between 1992 and 2001 were analyzed. Among these 250 cases, 16 cases were excluded from the study because the causative microorganism were not Streptococcus pyogenes. 234 strains of S. pyogenes obtained from the aforementioned 234 cases were tested for T-type by a serological method, and for streptococcal pyrogenic exotoxin (SPE) by in vitro productivity of the toxin as well as molecular genetic methods. The number of patients was 141 (56.4%) for males, and 107 (42.8%) for females. The highest frequency of STSS was observed in those patients in their sixties in both sexes. The overall mortality rate was 43.2%. The mortality rate for male was 36.9%, and 52.3% for female. Bacteriological studies revealed that most common T types were T1 and T3. These strains consisted 54.3% of the strains collected. Among strains of T1 type, 98.8% possessed genes of spe A, and 46.1% were shown to produce SPE A in vitro. Among strains of T3 type, 82.9% possessed spe A gene, and all of these strains were shown to produce the toxin in vitro. It is concluded that certain strains of S. pyogenes, such as those with T1, or T3 type, and those with spe A gene or in vitro production of SPE A, are the most frequent cause of STSS. Although infections caused by such bacteria are quite common, STSS rarely occurs in most such patients. Additional factors, such as host factors, may play a crucial role in the pathogenesis of STSS.
机译：为了调查临床和微生物学特征的临床和微生物学特征，分析了1992年至2001年间250名患者获得的临床，流行病学和从250名患者中获得的细菌数据。在这250例中，从研究中排除了16例，因为致病微生物不是链球菌的细胞活性。通过血清学法测试从上述234例中获得的234例中获得的S.的菌株的菌株。患者的数量为男性为141（56.4％），女性为107（42.8％）。在两性两性的患者中观察到STS的最高频率。总体死亡率为43.2％。男性的死亡率为36.9％，女性为52.3％。细菌学研究表明，大多数常见的T型是T1和T3。这些菌株组成54.3％的菌株。在T1型菌株中，98.8％具有SPE A的基因和46.1％的基因被显示为体外产生SPE。在T3型菌株中，82.9％具有SPE基因，并且显示所有这些菌株在体外产生毒素。结论是，某些S. pyogenes的菌株，例如具有T1或T3型的菌株，以及具有SPE A基因或体外生产的SPE A的菌株是STS的最常见原因。虽然这种细菌引起的感染是相当常见的，但在大多数此类患者中，STS很少发生。额外的因素，例如宿主因子，可能在STS的发病机制中发挥至关重要的作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号