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首页> 外文期刊>感染症学雑誌 >Epidemiological investigation of 'beta-lactam antibiotic induced vancomycin-resistant MRSA (BIVR)'
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Epidemiological investigation of 'beta-lactam antibiotic induced vancomycin-resistant MRSA (BIVR)'

机译：“β-内酰胺类抗生素诱导的耐万古霉素的MRSA（BIVR）”的流行病学调查

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Mu3 strain with heterogeneous intermediated-resistance to vancomycin (hetero-VISA) reported in 1997, also have possessed a character of an antagonistic effect of beta-lactam antibiotics and vancomycin. Mu3 is only strain which satisfies the definition of hetero-VISA in Japan. But, MRSA with antagonistic effects of beta-lactam antibiotics and vancomycin, was reported by many institutions. To separate hetero-VISA, we called "beta-lactam antibiotic induced vancomycin-resistant MRSA (BIVR)". But the detection rate of clinical isolated BIVR in Japan is unknown, we reported on the detection method and the epidemiological investigation for BIVR. Mu 3 agar containing 4 micrograms/mL of vancomycin is used to detect BIVR. Mu3 strains were spread on the agar, BIVR can grow around the paper disc impregnated with ceftizoxime or grow on the whole surface on Mu 3 agar after incubation. The detection rate of BIVR was 45 in 717 (6.3%) clinical isolated strains. In detected strains as BIVR, the number of strains with grown on the whole surface of Mu3 agar showing a high resistance to vancomycin were 10 strains (1.4%). Besides, from 106 strains of blood isolates MRSA, BIVR were detected 16 strains (15.1%), from 611 strains of non-blood isolates MRSA, BIVR were detected 29 strains (4.7%) (P < 0.0001). In BIVR strains grown on the whole surface of Mu3 agar, the number of BIVR strains isolated from blood were 8 in 106 (7.5%), from non-blood were 2 in 611 (0.3%) (P < 0.0001). On one side, hetero-VISA were not detected from all of BIVR growing on the whole surface of Mu3 agar. As a result, detection method and the definition of BIVR were quite different from those of hetero-VISA. An existence of BIVR in Japan was confirmed, we thought that the high detection rate of BIVR isolated from blood compared with that of non-blood showed the pathogenecity of BIVR which contribute to MRSA infections.
机译：1997年报道的对万古霉素具有异质中间耐药性的Mu3菌株（杂合VISA）也具有β-内酰胺类抗生素和万古霉素的拮抗作用。在日本，Mu3是唯一满足异源VISA定义的菌株。但是，许多机构已经报道了具有β-内酰胺抗生素和万古霉素拮抗作用的MRSA。为了分离异质VISA，我们将其称为“β-内酰胺类抗生素诱导的耐万古霉素的MRSA（BIVR）”。但是在日本，临床分离的BIVR的检出率尚不清楚，我们报道了BIVR的检测方法和流行病学调查。含有4微克/毫升万古霉素的Mu 3琼脂用于检测BIVR。 Mu3菌株被分散在琼脂上，孵育后，BIVR可以在浸渍有头孢唑肟的纸盘周围生长或在Mu 3琼脂的整个表面上生长。在717例临床分离株中，BIVR的检出率为45（6.3％）。在作为BIVR的检测菌株中，在对万古霉素具有高抗性的Mu3琼脂的整个表面上生长的菌株数量为10个菌株（1.4％）。此外，从106株血液分离株MRSA中检测出BIVR 16株（15.1％），从611株非血液分离株MRSA中检测到BIVR 29株（4.7％）（P <0.0001）。在Mu3琼脂整个表面上生长的BIVR菌株中，从血液中分离出的BIVR菌株的数量为106例中的8例（7.5％），非血液中611例中的2例（0.3％）（P <0.0001）。一方面，未从在Mu3琼脂的整个表面上生长的所有BIVR中都检测到异源VISA。结果，BIVR的检测方法和定义与异类VISA完全不同。日本已确认存在BIVR，我们认为从血液中分离出的BIVR与非血液相比具有较高的检出率，表明BIVR的致病性有助于MRSA感染。

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