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首页> 外文期刊>感染症学雑誌 >Epidemiological investigation of beta-lactam antibiotic induced vancomycin-resistant MRSA from clinical isolated MRSA--comparison of detection rate of BIVR with or without CZX
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Epidemiological investigation of beta-lactam antibiotic induced vancomycin-resistant MRSA from clinical isolated MRSA--comparison of detection rate of BIVR with or without CZX

机译：临床分离的MRSA对β-内酰胺类抗生素诱导的耐万古霉素MRSA的流行病学研究-含或不含CZX的BIVR的检出率比较

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摘要

Recently, beta-lactam antibiotic induced vancomycin-resistant MRSA (BIVR) has been reported increasingly in Japan. Between 1998 and 2002, we tried to detect BIVR from 500 strains of MRSA in a cancer hospital. And the difference of the detection rate under condition of pre-culture with or without ceftizoxime was compared. The detection rate of BIVR under condition of pre-culture with 1.0 mg/L of ceftizoxime was 20.4% (102/500), and without ceftizoxime was 9% (45/500). That of preculture with 1.0 mg/L of ceftizoxime was higher than those without ceftizoxime with the significant difference. (p < 0.001; McNemar-t examination). In comparing each department, the detection rate of BIVR from Chemotherapy, Head & Neck, and Urology department was 33.3%, 27.0%, and 20.0%, respectively. These results mean that addition of beta-lactam as ceftizoxime in pre-culture induces the ability of resistance to vancomycin for MRSA having a capacity as BIVR.
机译：最近，在日本越来越多地报道了β-内酰胺类抗生素诱导的耐万古霉素的MRSA（BIVR）。在1998年至2002年之间，我们尝试在一家癌症医院从500株MRSA菌株中检测出BIVR。比较了有或没有头孢唑肟预培养条件下的检出率差异。预培养1.0 mg / L的头孢唑肟条件下BIVR的检出率为20.4％（102/500），而没有头孢唑肟的培养率为9％（45/500）。头孢唑肟1.0 mg / L的预培养比未头孢唑肟的预培养高，差异有统计学意义。 （p <0.001; McNemar-t检验）。在比较各个部门时，化学疗法，头颈和泌尿科的BIVR检出率分别为33.3％，27.0％和20.0％。这些结果意味着在预培养中添加β-内酰胺作为头孢唑肟可诱导具有BIVR能力的MRSA对万古霉素具有抗性。

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