• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Comparative Medicine >Modeling perimenopause in sprague-dawley rats by chemical manipulation of the transition to ovarian failure.
【24h】

Modeling perimenopause in sprague-dawley rats by chemical manipulation of the transition to ovarian failure.

机译：通过化学操作过渡到卵巢衰竭，在sprague-dawley大鼠中围绝经期建模。

获取原文
获取原文并翻译 | 示例
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Various age-related diseases increase in incidence during perimenopause. However, our understanding of the effects of aging compared with hormonal changes of perimenopause in mediating these disease risks is incomplete, in part due to the lack of an experimental perimenopause model. We therefore aimed to determine whether manipulation of the transition to ovarian failure in rats via the use of 4-vinylcyclohexene diepoxide (VCD) could be used to model and accelerate hormonal changes characteristic of perimenopause. We examined long-term (11 to 20 mo), dose-dependent effects of VCD on reproductive function in 1- and 3-mo-old female Sprague-Dawley rats. Twenty-five daily doses of VCD (80 or 160 mg/kg daily compared with vehicle alone) depleted ovarian follicles in a dose-dependent fashion in rats of both ages, accelerated the onset of acyclicity, and caused dose-dependent increases in follicle-stimulating hormone that exceeded those naturally occurring with age in control rats but left serum levels of 17beta-estradiol unchanged, with continued ovarian production of androstenedione. High-dose VCD caused considerable nonovarian toxicities in 3-mo-old Sprague-Dawley rats, making this an unsuitable model. In contrast, 1-mo-old rats had more robust dose-dependent increases in follicle-stimulating hormone without evidence of systemic toxicity in response to either VCD dose. Because perimenopause is characterized by an increase in follicle-stimulating hormone with continued secretion of ovarian steroids, VCD acceleration of an analogous hormonal milieu in 1-mo-old Sprague-Dawley rats may be useful for probing the hormonal effects of perimenopause on age-related disease risk.
机译：各种与年龄有关的疾病在围绝经期发病率增加。然而，由于缺乏实验性围绝经模型，我们对衰老与围绝经期激素变化相比对介导这些疾病风险的影响的理解是不完整的。因此，我们旨在确定是否可以通过使用4-乙烯基环己烯二环氧化合物（VCD）操纵大鼠向卵巢衰竭的过渡来建模和加速绝经前特征性激素变化。我们检查了VCD对1个月和3个月大的雌性Sprague-Dawley大鼠生殖功能的长期（11至20 mo）剂量依赖性效应。每天25剂量的VCD（与单独使用溶媒相比，每天80或160 mg / kg剂量）消耗卵巢卵泡，这在两个年龄的大鼠中均呈剂量依赖性，加速了非循环性的发作，并导致卵泡中剂量依赖性增加。刺激性激素超过对照组大鼠中自然产生的激素，但血清17β-雌二醇水平保持不变，并且卵巢中雄烯二酮持续产生。大剂量VCD在3个月大的Sprague-Dawley大鼠中引起相当大的非卵巢毒性，使其成为不合适的模型。相比之下，1个月大的大鼠的卵泡刺激激素剂量依赖性增加，但对任何VCD剂量均无全身毒性证据。由于围绝经期的特点是卵泡刺激激素增加，并持续分泌卵巢类固醇，因此，在1个月大的Sprague-Dawley大鼠中，类似激素环境的VCD加速可用于探讨围绝经期对与年龄相关的激素作用疾病风险。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号