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Atopic dermatitis in NC/jic mice associated with Myobia musculi infestation

机译：NC / jic小鼠伴有肌层肌肉感染的特应性皮炎

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The NC(NC/Nga) mouse strain was established as an inbred strain by Kondo in 1957 on the basis on Japanese fancy mice (1, 2). The NC/Nga mice were originally recognized as an autoimmune disease model mice and were known to manifest signs of a numberof disorders. Dermatitis with extremely high incidence was the most evident disorder in NC/Nga mice (1, 3, 4). In 1997, Matsuda et al. documented that NC/Nga mouse dermatitis is a model of human atopic dermatitis (AD) (5). According to Matsuda, NC/Nga mice develop skin lesions that are clinically and histologically similar to human AD, spontaneously appearing on the face, neck, ears, and dorsal skin of the mice. Plasma concentration of total immunoglobulin E (IgE) in the mice is markedly high from eightweeks of age, correlating with the clinical severity of dermatitis. One important aspect of the NC/Nga strain as a human AD model is that the lesions of the mice appear when they are raised under non-sterile (conventional) circumstances, but not under specific-pathogen-free (SPF) conditions. Thus, NC/Nga mice suffer from dermatitis similar to human AD, with IgE hyperproduction, which may be triggered by some environmental factor(s). Although the possibility of an allergic mechanism in the cause of thedermatitis of NC/Nga mice was reported (6), others denied the immunologic mechanism in the course of the development of the dermatitis (4). The cause of this dermatitis remained unclear.
机译：NC（NC / Nga）小鼠品系由Kondo于1957年在日本花式小鼠的基础上建立为近交系（1、2）。 NC / Nga小鼠最初被认为是自身免疫性疾病模型小鼠，已知会表现出多种疾病的迹象。在NC / Nga小鼠中，发生率极高的皮炎是最明显的疾病（1、3、4）。 1997年，松田等人。有文献记载，NC / Nga小鼠皮炎是人类特应性皮炎（AD）的模型（5）。据松田说，NC / Nga小鼠的皮肤病变在临床上和组织学上与人AD类似，自发出现在小鼠的面部，颈部，耳朵和背部皮肤上。从八周龄开始，小鼠中总免疫球蛋白E（IgE）的血浆浓度显着升高，这与皮炎的临床严重程度相关。 NC / Nga菌株作为人类AD模型的一个重要方面是，在非无菌（常规）情况下（而非特定无病原体（SPF））条件下饲养小鼠时，它们会出现损伤。因此，NC / Nga小鼠患有类似于人AD的皮炎，具有IgE高产，这可能是由某些环境因素触发的。尽管已经报道了在NC / Nga小鼠皮炎中可能存在过敏机制的可能性（6），但其他人否认在皮炎发展过程中的免疫机制（4）。这种皮炎的原因尚不清楚。

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