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Stress effects of 72-hour sleep deprivation

机译：72小时睡眠不足的压力影响

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Stress effects of 3-d (72-hr) continuous vigilance were studied for renal excretion of 17-oxycorticoids (17-KS), electrolytes (potassium and sodium), and liquid. The investigation involved 12 male subjects aged 23 to 36. Baseline parameters displayed diurnal variations with comparatively high day and comparatively low night values. During the 72-hr vigilance, significant and consistent (statistically fiducial) intensification of 17-KS and potassium excretion occurred in the night-time, i.e., in the period of naturally low values, but only in the first two sleepless nights. As for sodium and liquid excretion, stress-related reduction in these parameters was more consistent and distinct in the day-time, i.e., in the period of naturally high values, rather than in the nighttime. Therefore, the two factors that should be accounted for by investigators of continuous vigilance (and, maybe, other stresses) are the anticipated direction of a stress-reaction and baseline diurnal variation of parameters under study. If stress is expected to increase a parameter, measurements should be done when the parameter is naturally low and, vice versa, if stress is known to reduce a parameter, then measurement should be planned in the period when it is naturally high. If direction of stress-related changes is predictable, investigations can be performed on a twenty-four hour basis. environmental medicine
机译：研究了连续3天（72小时）保持警惕的应激效应，研究了17-氧皮质类固醇（17-KS），电解质（钾和钠）和液体的肾脏排泄情况。该调查涉及12位年龄在23至36岁之间的男性受试者。基线参数显示昼夜相对较高且昼夜变化较大。在72小时的警惕期间，夜间（即，在自然较低的值期间），但仅在前两个不眠之夜，发生了显着且一致的（统计基准）集约化17-KS和钾排泄。至于钠和液体的排泄，与压力有关的这些参数的减少在白天，即在自然高值时期而不是在夜间，更为一致和明显。因此，持续警惕（可能还有其他压力）的调查人员应考虑的两个因素是预期的压力反应方向和所研究参数的基线日变化。如果预期压力会增加参数，则应在参数自然较低时进行测量，反之亦然，如果已知压力会降低参数，则应计划在参数自然较高时进行测量。如果压力相关变化的方向是可预测的，则可以每24小时进行一次调查。环境医学

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