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Comparison of pentazocine and fentanyl in total intravenous anesthesia using propofol

机译：异丙酚全静脉麻醉中喷他佐辛和芬太尼的比较

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BACKGROUND: Pentazocine may be an alternative for fentanyl during total intravenous anesthesia (TIVA) using propofol. The authors compared the efficacy and safety of pentazocine for analgesics in TIVA using propofol. METHODS: Eighty-nine patients scheduled for mastectomy were analyzed retrospectively. Patients were classified into two groups by used analgesics; pentazocine (Group P, n = 34) and fentanyl (Group F, n = 55). Anesthesia was induced with propofol, using target controlled infusion method, and ketamine 20-50 mg, and was maintained with propofol infusion and increments of fentanyl or single dose of pentazocine with 40% oxygen in air. Postoperative pain was assessed using a visual analogue pain scale (VAS). RESULTS: There were no differences in the patient background between both groups. Systolic as well as diastolic blood pressure and heart rate were not different between both groups during surgery. The maintenance dose of propofol was not different between the two groups. Awakening time in about 80% of patients was within 15 minutes and is not different between the two groups. There were no differences between the two groups regarding VAS. There are no severe complications. Incidence of nausea and vomiting was not different between the two groups. CONCLUSIONS: The results suggest that pentazocine would provide a stable hemodynamic state, rapid recovery and an effective postoperative pain relief to the same degree as with fentanyl in TIVA with propofol.
机译：背景：在使用丙泊酚的全静脉麻醉（TIVA）期间，喷他佐辛可能是芬太尼的替代品。作者比较了使用丙泊酚的戊唑嗪镇痛药在TIVA中的有效性和安全性。方法：对89例行乳房切除术的患者进行回顾性分析。根据使用的止痛药将患者分为两类：喷他佐辛（P组，n = 34）和芬太尼（F组，n = 55）。使用靶控输注方法和浓度为20-50 mg的氯胺酮，使用异丙酚诱导麻醉，并通过异丙酚输注和芬太尼或单剂量喷他佐辛与空气中40％氧气的增量维持麻醉。使用视觉模拟疼痛量表（VAS）评估术后疼痛。结果：两组患者的背景无差异。两组在手术期间收缩压，舒张压和心率无差异。两组丙泊酚的维持剂量无差异。大约80％的患者的唤醒时间在15分钟内，两组之间没有差异。两组在VAS方面没有差异。没有严重的并发症。两组之间的恶心和呕吐发生率没有差异。结论：结果表明，喷他佐辛可以提供稳定的血液动力学状态，快速恢复和有效的术后疼痛缓解，其程度与异丙酚TIVA中的芬太尼相同。

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