• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Clinical and experimental allergy : >The impact of aluminium in acid-suppressing drugs on the immune response of BALB/c mice.
【24h】

The impact of aluminium in acid-suppressing drugs on the immune response of BALB/c mice.

机译：铝在抑酸药物中对BALB / c小鼠免疫反应的影响。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: Recently we have shown that anti-acid drugs lead to an enhanced risk of food allergy. This may be due to hindered peptic digestion, caused by an elevation of the gastric pH. Additionally, it is known that aluminium-linked antigens lead to an increased probability of sensitization. OBJECTIVE: Our aim in this study was to show whether sucralfate promotes sensitization not only by preventing peptic digestion but also by acting as a T-helper type 2 (Th2) adjuvant. METHODS: To avoid the effect of sucralfate on the gastric pH and to show only the adjuvant effect, BALB/c mice were immunized on the parenteral route with codfish extract plus sucralfate, and control groups with aluminium hydroxide (alum) (Th2 adjuvant) or monophosphoryl lipid A (MPL) (Th1 adjuvant). Antigen-specific antibodies and cytokine levels were determined. The in vivo effect was investigated by intradermal skin tests. RESULTS: Codfish-specific high IgG1 and IgE antibody levels as well as elevated IL-4 and IL-5 levels in alum- and MPL-treated mice, but more importantly also in sucralfate-treated mice, indicated a Th2 shift. Positive skin tests confirmed this Th2 response. CONCLUSIONS: Our data show that parenterally applied sucralfate is able to induce a Th2 response probably due to the aluminium content. This indicates that orally applied sucralfate may lead to an enhanced risk of food allergy not only by inhibiting peptic digestion but also by acting as a Th2 adjuvant.
机译：背景：最近我们已经表明，抗酸药会导致食物过敏的风险增加。这可能是由于胃pH升高引起的消化不良而引起的。另外，已知铝连接的抗原导致敏化的可能性增加。目的：我们的研究目的是证明硫糖铝是否不仅通过防止消化消化，而且还可以作为2型T辅助佐剂来促进敏化作用。方法：为避免硫糖铝对胃pH值的影响并仅显示佐剂作用，对BALB / c小鼠的肠胃外途径用鳕鱼提取物加硫糖铝酸盐进行免疫，对照组则用氢氧化铝（铝）（Th2佐剂）或单磷酰脂质A（MPL）（Th1佐剂）。确定了抗原特异性抗体和细胞因子水平。通过皮内皮肤试验研究了体内作用。结果：在用明矾和MPL处理的小鼠中，鳕鱼特异的高IgG1和IgE抗体水平以及升高的IL-4和IL-5水平，但更重要的是在用硫糖铝处理的小鼠中，表明Th2改变。皮肤试验阳性证实了这种Th2反应。结论：我们的数据表明，肠胃外施用硫糖铝能够诱导Th2反应，这可能是由于铝含量引起的。这表明口服硫糖铝可能不仅通过抑制消化消化而且还可以作为Th2佐剂，导致食物过敏的风险增加。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号