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Computer-aided characterization for effective mechanical properties of porous tissue scaffolds

机译：多孔组织支架有效机械性能的计算机辅助表征

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摘要

Performance of various functions of the tissue structure depends on porous scaffold microstractures with specific porosity characteristics that influence the behavior of the incorporated or ingrown cells. Understanding the mechanical properties of porous tissue scaffold is important for its biological and biomechanical tissue engineering application. This paper presents a computer aided characterization approach to evaluate the effective mechanical properties of porous tissue scaffold. An outline of a computer-aided tissue engineering approach for design and fabrication of porous tissue scaffold, procedure of computer-aided characterization and its interface with design model, development of a computational algorithm for finite element implementation and numerical solution of asymptotic homogenization theory is presented, Application of the algorithm to characterize the effective mechanical properties of porous poly-ε-caprolactone scaffold manufactured by precision extruding freeform deposition will also be presented, along with a parametric study of the process and design parameter to the structural properties of tissue scaffold.
机译：组织结构的各种功能的执行取决于具有特定孔隙率特征的多孔支架微结构，该结构影响所结合或向内生长的细胞的行为。了解多孔组织支架的机械特性对其生物学和生物力学组织工程应用非常重要。本文提出了一种计算机辅助表征方法，以评估多孔组织支架的有效机械性能。概述了用于多孔组织支架设计和制造的计算机辅助组织工程方法，计算机辅助表征的过程及其与设计模型的接口，有限元实现的计算算法的发展以及渐近均质化理论的数值解。 ，还将介绍该算法在表征通过精密挤压自由形式沉积制造的多孔聚ε-己内酯支架的有效机械性能以及对工艺和设计参数对组织支架结构特性的参数研究中的应用。

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