• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Brain research >Exogenous insulin-like growth factor 2 administration enhances memory consolidation and persistence in a time-dependent manner
【24h】

Exogenous insulin-like growth factor 2 administration enhances memory consolidation and persistence in a time-dependent manner

机译：外源性胰岛素样生长因子2的给药以时间依赖性方式增强记忆巩固和持久性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Memory consolidation is an important process for the formation of long-term memory. We have previously reported that mature brain-derived neurotrophic factor enhances memory consolidation within 9 h after initial learning. Recent studies suggest that insulin-like growth factor 2 (IGF2) significantly enhances memory consolidation and prevents forgetting. Thus, we hypothesized that IGF2 exerts its activity on cognitive performance in a time-dependent manner as observed in our previous study. In the one-trial step-through inhibitory avoidance task, we demonstrate that a bilateral injection of IGF2 into the dorsal hippocampus 6 or 9 h after training significantly enhanced the step-through latencies compared with the vehicle-treated controls in the retention trial, which was conducted 24 h after the acquisition trial. However, 12 h post-training, IGF2 injection did not increase the step-through latencies. Intriguingly, in the retention trial at 21 days after the training, hippocampal IGF2 injection 6, 9 or 12 h after the acquisition trial significantly increased the step-through latencies compared with the vehicle-treated controls. IGF2 administration at 9 h and 12 h after the acquisition trial significantly increased discrimination index and exploration time on the novel-located object in the test trial at 24h and 21 days, respectively, after the acquisition trial in the novel location recognition task. In addition, IGF2-induced an increase in the step-through latencies in the retention trial 24 h or 21 days, respectively, after the initial learning was completely abolished by co-injected anti-IGF2 receptor antibody. These results suggest that IGF2 enhances memory consolidation within 9 h after initial learning, and increased IGF2 within the 12 h after the acquisition trial, which represents a delayed consolidation phase, is also critical for memory persistence. (C) 2015 Elsevier B.V. All rights reserved.
机译：记忆整合是形成长期记忆的重要过程。我们以前曾报道过，成熟的脑源性神经营养因子可在初次学习后9小时内增强记忆巩固。最近的研究表明，胰岛素样生长因子2（IGF2）可以显着增强记忆巩固并防止遗忘。因此，我们假设如我们先前的研究中所观察到的，IGF2以时间依赖性方式发挥其对认知表现的作用。在一次试验性的逐步抑制性避免任务中，我们证明了在训练后6或9 h双向向背侧海马注射IGF2较保留试验中的媒介物对照组显着提高了逐步潜伏期。购置试用24小时后进行。但是，训练后12小时，IGF2注射并没有增加逐步潜伏期。有趣的是，在训练后21天的保留试验中，获得试验后第6、9或12 h注射海马IGF2与载体治疗的对照组相比，显着增加了逐步潜伏期。在新位置识别任务中，在获得试验之后的24小时和21天，分别在获得试验之后的9 h和12 h施用IGF2，显着增加了对试验中的新颖定位对象的辨别指数和探索时间。此外，在共学习抗IGF2受体抗体完全取消了初始学习后，IGF2分别在保留试验中24 h或21天诱导了逐步潜伏期的增加。这些结果表明，IGF2在初次学习后9小时内增强了记忆整合，而在获得性试验后的12小时内增加了IGF2，这代表了延迟的整合阶段，对于记忆持久性也至关重要。 （C）2015 Elsevier B.V.保留所有权利。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号