Synthesis of Pyridazinones through the Copper(I)-Catalyzed Multicomponent Reaction of Aldehydes, Hydrazines, and Alkynylesters

Anderson C. Mantovani; Tales A. C. Goulart; Davi F. Back; Gilson Zeni

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Synthesis of Pyridazinones through the Copper(I)-Catalyzed Multicomponent Reaction of Aldehydes, Hydrazines, and Alkynylesters

机译：通过铜（I）催化的醛类，肼类和炔基酯的多组分反应合成哒嗪酮

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The copper-catalyzed multicomponent cyclization reaction, which combined aldehydes, hydrazines, and alkynylesters, was applied in the synthesis of pyridazinones. The reaction was regioselective and gave only six-membered pyridazinones in the complete absence of five-membered pyrazoles or a regioisomeric mixture. During this investigation, the use of 2-halobenzaldehyde as the starting material, under identical reaction conditions, gave 6-(2-ethoxyphenyl)-pyridazinones after sequential Michael addition/1,2-addition/Ullmann cross-coupling reactions.

机译：铜催化的多组分环化反应（结合了醛，肼和炔基酯）被用于合成哒嗪酮。该反应是区域选择性的，在完全不存在五元吡唑或区域异构体混合物的情况下，仅给出六元哒嗪酮。在该研究过程中，在相同的反应条件下，使用2-卤代苯甲醛作为起始原料，在依次进行迈克尔加成/ 1,2-加成/乌尔曼交叉偶联反应后得到6-（2-乙氧基苯基）-哒嗪酮。

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《Chemistry: A European journal》 |2014年第39期|共6页
作者
Anderson C. Mantovani; Tales A. C. Goulart; Davi F. Back; Gilson Zeni;
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正文语种 eng
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copper; cyclization; heterocycles; homogeneous catalysis; multicomponent reactions;

机译：铜;环化;杂环;均相催化;多组分反应;

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1. Synthesis of Pyridazinones through the Copper(I)-Catalyzed Multicomponent Reaction of Aldehydes, Hydrazines, and Alkynylesters [J] . Anderson C. Mantovani, Tales A. C. Goulart, Davi F. Back, Chemistry: A European journal . 2014,第39期

机译：通过铜（I）催化的醛类，肼类和炔基酯的多组分反应合成哒嗪酮
2. Solvent-free and montmorillonite K10-catalyzed domino reactions for the synthesis of pyrazoles with alkynylester as a dual synthon [J] . Green chemistry . 2020,第8期

机译：无溶剂和Montmorillonite K10催化的Domino反应，用炔基酯合成吡唑，作为双合成剂
3. Diverse synthesis of pyrimido[1,2-a]benzimidazoles and imidazo[2,1-b]benzothiazoles via CuI-catalyzed decarboxylic multicomponent reactions of heterocyclic azoles, aldehydes and alkynecarboxylic acids [J] . Wu Jiarong, Luo Huan, Wang Tao, Tetrahedron . 2019,第8期

机译：通过Cui催化的杂环唑烷基苯并羧酸脱羧的脱羧多组分反应，亚醛和炔萘酸的多元化物，吡啶胺[1,2-A]苯并咪唑和咪唑和亚咪唑的多样化合成
4. Synthesis of α-Fluoroimines from Copper-Catalyzed Reactions of Diarylacetylenes and N-Fluorobenzenesulfonimide [C] . Shu Jan Yip, Tetsushi Yoshidomi, Kei Murakami 日本化学会春季年会講演予稿集 . 2018

机译：二芳基乙烯基铜催化反应的α-氟杂质的合成，N-氟苯磺酰胺
5. Design of copper-catalyzed multicomponent reactions and applications to natural product synthesis. [D] . Meng, Fanke. 2015

机译：铜催化多组分反应的设计及其在天然产物合成中的应用。
6. Enantioselective Multicomponent Condensation Reactions of Phenols Aldehydes and Boronates Catalyzed by Chiral Biphenols [O] . Keith S. Barbato, Yi Luan, Daniele Ramella, -1

机译：手性双酚催化苯酚醛和硼酸酯的对映选择性多组分缩合反应
7. Synthesis of 2,1-Benzoisoxazole-Containing 1,2,3-Triazoles through Copper-Catalyzed Three-Component Domino Reactions of oBromoacetophenones, Aldehydes, and Sodium Azide [O] . -1

机译：通过铜催化的大酮酮酮，醛和叠氮化钠的铜催化的三组分Domino反应合成含2,1-苯并异恶唑的1,2,3-三唑

Synthesis of Pyridazinones through the Copper(I)-Catalyzed Multicomponent Reaction of Aldehydes, Hydrazines, and Alkynylesters

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