Ynamide Carbopalladation: A Flexible Route to Mono-, Bi- and Tricyclic Azacycles

Campbell Craig D.; Greenaway Rebecca L.; Holton Oliver T.; Walker P. Ross; Chapman Helen A.; Russell C. Adam; Carr Greg; Thomson Amber L.; Anderson Edward A.

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Ynamide Carbopalladation: A Flexible Route to Mono-, Bi- and Tricyclic Azacycles

机译：酰胺酰胺碳酸酯化：单，双和三环氮杂环的灵活途径

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Bromoenynamides represent precursors to a diversity of azacycles by a cascade sequence of carbopalladation followed by cross-coupling/electrocyclization, or reduction processes. Full details of our investigations into intramolecular ynamide carbopalladation are disclosed, which include the first examples of carbopalladation/cross-coupling reactions using potassium organotrifluoroborate salts; and an understanding of factors influencing the success of these processes, including ring size, and the nature of the coupling partner. Additional mechanistic observations are reported, such as the isolation of triene intermediates for electrocyclization. A variety of hetero-Diels-Alder reactions using the product heterocycles are also described, which provide insight into Diels-Alder regioselectivity.

机译：溴代乙酰胺通过碳a的级联序列，交叉偶联/电环化或还原过程代表各种氮杂环的前体。公开了我们对分子内乙酰胺碳pal的研究的全部细节，包括使用有机三氟硼酸钾盐进行碳pal /交叉偶联反应的第一个例子;以及对影响这些过程成功的因素的理解，包括环的大小和耦合对象的性质。据报道，还有其他的机械观察，例如用于电环化的三烯中间体的分离。还描述了使用产物杂环的各种杂-Diels-Alder反应，可深入了解Diels-Alder区域选择性。

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《Chemistry: A European journal》 |2015年第36期|共13页
作者
Campbell Craig D.; Greenaway Rebecca L.; Holton Oliver T.; Walker P. Ross; Chapman Helen A.; Russell C. Adam; Carr Greg; Thomson Amber L.; Anderson Edward A.;
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domino reactions; hetero-Diels-Alder reactions; palladium catalysis; Suzuki coupling; ynamides;

机译：多米诺反应;杂Diels-Alder反应;钯催化;铃木偶联;酰胺;

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1. Ynamide Carbopalladation: A Flexible Route to Mono-, Bi- and Tricyclic Azacycles [J] . Campbell Craig D., Greenaway Rebecca L., Holton Oliver T., Chemistry: A European journal . 2015,第36期

机译：酰胺酰胺碳酸酯化：单，双和三环氮杂环的灵活途径
2. Synthesis of enantioenriched γ-quaternary cycloheptenones using a combined allylic alkylation/Stork-Danheiser approach: preparation of mono-, bi-, and tricyclic systems [J] . Nathan B. Bennett, Allen Y. Hong, Andrew M. Harned, Organic & biomolecular chemistry . 2012,第1期

机译：使用烯丙基烷基化/ Stork-Danheiser组合方法合成对映体富集的γ-季环庚烯酮：单环，双环和三环系统的制备
3. Facile domino access to chiral mono-, bi-, and tricyclic 2,3-dihydrofurans [J] . Fan L.-P., Li P., Li X.-S., The Journal of Organic Chemistry . 2010,第24期

机译：方便的多米诺获得手性单环，双环和三环2,3-二氢呋喃
4. Preparation of Nanorefrigerants using Mono-, Bi- and Tri-layer Graphene Nanosheets in R134a Refrigerant [C] . P.B. Maheshwary, C.C. Handa, K.R. Nemade International Conference on "Multidimensional Role of Basic Science in Advanced Technology" . 2019

机译：R134A制冷剂单，二层石墨烯纳米片的制备纳米福利剂
5. The coordination chemistry of a chelating tricyclic bisamidine and a new synthetic route to a C(2)-symmetric tricyclic bisamidine [D] . Li, Jingwei 2007

机译：螯合三环双am的配位化学和一个新的合成路线到C（2）对称三环双am
6. Ynamide Carbopalladation: A Flexible Route to Mono- Bi- and Tricyclic Azacycles [O] . Craig D Campbell, Rebecca L Greenaway, Oliver T Holton, -1

机译：酰胺酰胺碳酸酯化：单双和三环氮杂环的灵活途径
7. Synthesis of enantioenriched γ-quaternary cycloheptenones using a combined allylic alkylation/Stork–Danheiser approach: preparation of mono-, bi-, and tricyclic systems [O] . Bennett, Nathan B., Hong, Allen Y., Harned, Andrew M., 2012

机译：使用烯丙基烷基化/ Stork–Danheiser组合方法合成对映体富集的γ-季环庚烯酮：制备单环，双环和三环系统

Ynamide Carbopalladation: A Flexible Route to Mono-, Bi- and Tricyclic Azacycles

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