Cu-Catalyzed Intramolecular Amidation of Unactivated C(sp(3))-H Bonds To Synthesize N-Substituted Indolines

Pan Fei; Wu Bin; Shi Zhang-Jie

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Cu-Catalyzed Intramolecular Amidation of Unactivated C(sp(3))-H Bonds To Synthesize N-Substituted Indolines

机译：铜催化的未激活的C（sp（3））-H键的分子内酰胺化合成N-取代的二氢吲哚

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A copper-catalyzed intramolecular amidation of unactivated C(sp(3))-H bonds to construct indoline derivatives has been developed. Such an amidation proceeded well at primary C-H bonds preferred to secondary C-H bonds. The transformation owned a broad substrate scope. The corresponding indolines were obtained in good to excellent yields. N-Formal and other carbonyl groups were suitable and were easily deprotected and transformed into methyl or long-chained alkyl groups. Preliminary mechanistic studies suggested a radical pathway.

机译：铜催化分子内酰胺化的未激活的C（sp（3））-H键来构造吲哚啉衍生物。这样的酰胺化在优选于仲C-H键的伯C-H键处进行得很好。转型拥有广阔的基础范围。获得了相应的二氢吲哚，收率为好至极好。 N-甲醛和其他羰基是合适的，并且容易脱保护并转化为甲基或长链烷基。初步的力学研究表明了一个根本途径。

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《Chemistry: A European journal》 |2016年第19期|共4页
作者
Pan Fei; Wu Bin; Shi Zhang-Jie;
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正文语种 eng
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C-H activation; copper; indoline; radical; synthetic methods;

机译：碳氢活化;铜;二氢吲哚;自由基;合成方法;

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1. Cu-Catalyzed Intramolecular Amidation of Unactivated C(sp(3))-H Bonds To Synthesize N-Substituted Indolines [J] . Pan Fei, Wu Bin, Shi Zhang-Jie Chemistry: A European journal . 2016,第19期

机译：铜催化的未激活的C（sp（3））-H键的分子内酰胺化合成N-取代的二氢吲哚
2. Intramolecular, Site-Selective, Iodine-Mediated, Amination of Unactivated (sp(3))C-H Bonds for the Synthesis of Indoline Derivatives [J] . Long Jinguo, Cao Xin, Zhu Longzhi, Organic letters . 2017,第11期

机译：分子内，位点选择，碘介导的，未激活的胺化（SP（3））C-H键合成吲哚衍生物
3. Palladium-Catalyzed Amidation of Unactivated C(sp3)-H Bonds: from Anilines to Indolines [J] . Julia J. Neumann, Souvik Rakshit, Thomas Droge Angewandte Chemie . 2009,第37期

机译：钯催化未活化的C（sp3）-H键的酰胺化反应：从苯胺到二氢吲哚
4. Conjugated Oligomers Forming an Intramolecular Hydrogen Bonding: Twisted Conformation and Excited-State Intramolecular Proton Transfer [C] . Koji Takagi, Shin-ichi Matsuoka, Masato Suzuki World multi-conference on systemics, cybernetics and informatics;WMSCI 2008;ISAS;International conference on Information systems analysis and synthesis;International symposium on management, engineering and informatics;MEI 2008 . 2008

机译：共轭低聚物形成分子内氢键：扭曲构象和激发态分子内质子转移。
5. Carbon-hydrogen bond functionalization via hydride transfer: Development of catalytic carbon-carbon bond forming reactions via intramolecular coupling of sp3 carbon hydrogen bonds and activated alkenes. [D] . McQuaid, Kevin Michael. 2009

机译：通过氢化物转移进行碳氢键官能化：通过sp3碳氢键与活化烯烃的分子内偶联，发展催化碳-碳键形成反应。
6. Dithiane-directed Rh(iii)-catalyzed amidation of unactivated C(sp3)–H bonds [O] . Heyao Shi, Darren J. Dixon 2019

机译：二噻吩定向的Rh（iii）催化的未活化C（sp3）–H键的酰胺化
7. Intermolecular amidation of unactivated sp2 and sp3 C-H bonds via palladium-catalyzed cascade C-H activation/nitrene insertion [O] . Thu HY, Yu WY, Che CM 2006

机译：未激活的sp2和sp3 C-H键的分子间酰胺化作用，通过钯催化的级联C-H激活/硝烯插入

Cu-Catalyzed Intramolecular Amidation of Unactivated C(sp(3))-H Bonds To Synthesize N-Substituted Indolines

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