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首页> 外文期刊>ACS applied materials & interfaces >Temperature-Responsive Smart Nanocarriers for Delivery Of Therapeutic Agents: Applications and Recent Advances
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Temperature-Responsive Smart Nanocarriers for Delivery Of Therapeutic Agents: Applications and Recent Advances

机译：温度敏感型智能纳米载体用于治疗药物的输送：应用和最新进展

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摘要

Smart drug delivery systems (DDSs) have attracted the attention of many scientists, as carriers that can be stimulated by changes in environmental parameters such as temperature, pH, light, electromagnetic fields, mechanical forces, etc. These smart nanocarriers can release their cargo on demand when their target is reached and the stimulus is applied. Using the techniques of nanotechnology, these nanocarriers can be tailored to be target-specific, and exhibit delayed or controlled release of drugs. Temperature-responsive nanocarriers are one of most important groups of smart nanoparticles (NPs) that have been investigated during the past decades. Temperature can either act as an external stimulus when heat is applied from the outside, or can be internal when pathological lesions have a naturally elevated termperature. A low critical solution temperature (LCST) is a special feature of some polymeric materials, and most of the temperature-responsive nanocarriers have been designed based on this feature. In this review, we attempt to summarize recent efforts to prepare innovative temperature-responsive nanocarriers and discuss their novel applications.
机译：智能药物输送系统（DDS）引起了许多科学家的关注，因为可以通过环境参数（例如温度，pH，光，电磁场，机械力等）的变化来刺激载体。这些智能纳米载体可以在达到目标并实施刺激时的需求。使用纳米技术，可以将这些纳米载体定制为目标特异性的，并表现出药物的延迟或控制释放。温度响应型纳米载体是过去几十年来研究的最重要的智能纳米颗粒（NP）组之一。当从外部施加热量时，温度可以充当外部刺激，或者当病理性病变的温度自然升高时可以成为内部刺激。低临界溶液温度（LCST）是某些聚合物材料的一个特殊功能，并且大多数基于温度响应的纳米载体都是基于此功能设计的。在这篇综述中，我们试图总结最近为制备创新的温度响应纳米载体所做的努力，并讨论它们的新颖应用。

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