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首页> 外文期刊>American Journal of Physiology >Muscle-derived expression of the chemokine CXCL1 attenuates diet-induced obesity and improves fatty acid oxidation in the muscle
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Muscle-derived expression of the chemokine CXCL1 attenuates diet-induced obesity and improves fatty acid oxidation in the muscle

机译：肌源性趋化因子CXCL1的表达可减轻饮食引起的肥胖症，并改善肌肉中的脂肪酸氧化

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Serum levels and muscle expression of the chemokine CXCL1 increase markedly in response to exercise in mice. Because several studies have established muscle-derived factors as important contributors of metabolic effects of exercise, this study aimed at investigating the effect of increased expression of muscle-derived CXCL1 on systemic and intramuscular metabolic parameters, with focus on fatty acid oxidation and oxidative metabolism in skeletal muscle. By overexpression of CXCL1 in the tibialis cranialis muscle in mice, significant elevations in muscle and serum CXCL1 within a physiological range were obtained. At 3 mo of high-fat feeding, visceral and subcutaneous fat mass were 32.4 (P < 0.01) and 22.4% (P < 0.05) lower, respectively, in CXCL1-overex-pressing mice compared with control mice. Also, chow-fed CXCL-transfected mice had 35.4% (P < 0.05) lower visceral fat mass and 33.4% (P < 0.05) lower subcutaneous fat mass compared with chow-fed control mice. These reductions in accumulation of adipose tissue were accompanied by improved glucose tolerance and insulin sensitivity. Furthermore, in CXCL1-transfected muscles, muscular ex vivo fatty acid oxidation was significantly enhanced compared with control muscles (chow fed: 2.2-fold, P < 0.05; high-fat fed: 2-fold, P < 0.05) and also showed increased expression levels of major fatty acid oxidation genes (CD36, CPT I, and HADH). Finally, CXCL1 expression was associated with increased muscle mRNA expression of VEGF and CD31, suggesting a role for CXCL1 in muscle angio-genesis. In conclusion, our data show that overexpression of CXCL1 within a physiological range attenuates diet-induced obesity, likely mediated through a CXCL1-induced improvement of fatty acid oxidation and oxidative capacity in skeletal muscle tissue. ? 2012 the American Physiological Society.
机译：趋化因子CXCL1的血清水平和肌肉表达在小鼠中响应运动而显着增加。由于数项研究已将肌肉来源的因素确定为运动代谢作用的重要贡献者，因此本研究旨在研究增加肌肉来源的CXCL1的表达对全身和肌肉内代谢参数的影响，重点研究脂肪酸的氧化和氧化代谢。骨骼肌。通过在小鼠的胫骨胫骨肌中过度表达CXCL1，可在生理范围内获得肌肉和血清CXCL1的显着升高。与对照组相比，高脂喂养3个月时，CXCL1过表达小鼠的内脏和皮下脂肪量分别降低了32.4（P <0.01）和22.4％（P <0.05）。此外，与用普通食物喂养的对照小鼠相比，用CXCL饮食喂养的CXCL转染小鼠的内脏脂肪质量降低了35.4％（P <0.05），而皮下脂肪质量降低了33.4％（P <0.05）。脂肪组织积累的这些减少伴有改善的葡萄糖耐量和胰岛素敏感性。此外，在CXCL1转染的肌肉中，与对照肌肉相比，肌肉离体脂肪酸氧化显着增强（低脂喂养：2.2倍，P <0.05;高脂喂养：2倍，P <0.05），并且还显示出增加主要脂肪酸氧化基因（CD36，CPT I和HADH）的表达水平。最后，CXCL1表达与VEGF和CD31的肌肉mRNA表达增加相关，提示CXCL1在肌肉血管生成中的作用。总之，我们的数据表明CXCL1在生理范围内的过表达减弱了饮食引起的肥胖，这可能是由CXCL1引起的骨骼肌组织中脂肪酸氧化和氧化能力的改善介导的。 ？ 2012年美国生理学会。

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