首页> 外文期刊>Neuroscience: An International Journal under the Editorial Direction of IBRO >THE HETEROGENEITY OF VENTRAL TEGMENTAL AREA NEURONS: PROJECTION FUNCTIONS IN A MOOD-RELATED CONTEXT
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THE HETEROGENEITY OF VENTRAL TEGMENTAL AREA NEURONS: PROJECTION FUNCTIONS IN A MOOD-RELATED CONTEXT

机译:室侧区神经元的异质性:与情绪相关的上下文中的投影功能

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摘要

The ventral tegmental area (VTA) in the brain's reward circuitry is composed of a heterogeneous population of dopamine, GABA, and glutamate neurons that play important roles in mediating mood-related functions including depression. These neurons project to different brain regions, including the nucleus accumbens (NAc), the medial prefrontal cortex (mPFC), and the amygdala. The functional understanding of these projection pathways has been improved since the extensive use of advanced techniques such as viral-mediated gene transfer, cell-type-specific neurophysiology and circuit-probing optogenetics. In this article, we will discuss the recent progress in understanding these VTA projection-specific functions, focusing on mood-related disorders.
机译:大脑奖励电路中的腹侧被盖区(VTA)由多巴胺,GABA和谷氨酸神经元的异质群体组成,它们在介导与情绪相关的功能(包括抑郁症)中起重要作用。这些神经元投射到不同的大脑区域,包括伏伏核(NAc),内侧前额叶皮层(mPFC)和杏仁核。自从广泛使用先进技术(如病毒介导的基因转移,特定于细胞类型的神经生理学和电路探测光遗传学)以来,对这些投射途径的功能性理解已有所改善。在本文中,我们将讨论在了解这些VTA投影特定功能方面的最新进展,重点是与情绪相关的疾病。

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