A concise asymmetric total synthesis for structure elucidation of 5,6-secoiridoid from Incarvillea argute

Fu Jian-Jun; Liu Zhi-Qian; Jin Hui-Zi; Zhang Shou-De; Sun Qing-Yan; Zhang Wei-Dong

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A concise asymmetric total synthesis for structure elucidation of 5,6-secoiridoid from Incarvillea argute

机译：简洁的不对称全合成，用于从Incarvillea argute解析5,6-secoiridoid

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A phytochemical investigation of the roots of Incarvillea arguta led to the isolation of secoarguterin (1), which is the first example of 5,6-secoiridoid. Its structure and absolute configuration was elucidated by extensive spectral analysis and total synthesis. Compound 1 showedmoderate inhibition against human colon cancer cells HCT116 with an IC50 value of 28.72 mu M.

机译：对食蟹小食蟹（Incarvillea arguta）根进行植物化学研究后，分离出了芥子油精（1），这是5,6-secoiridoid的第一个实例。通过广泛的光谱分析和总合成阐明了其结构和绝对构型。化合物1对人结肠癌细胞HCT116表现出中等抑制作用，IC50值为28.72μM。

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《RSC Advances》 |2016年第76期|共4页
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Fu Jian-Jun; Liu Zhi-Qian; Jin Hui-Zi; Zhang Shou-De; Sun Qing-Yan; Zhang Wei-Dong;
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1. A concise asymmetric total synthesis for structure elucidation of 5,6-secoiridoid from Incarvillea argute [J] . Fu Jian-Jun, Liu Zhi-Qian, Jin Hui-Zi, RSC Advances . 2016,第76期

机译：简洁的不对称全合成，用于从Incarvillea argute解析5,6-secoiridoid
2. Phellilane L, Sesquiterpene Metabolite of Phellinus linteus: Isolation, Structure Elucidation, and Asymmetric Total Synthesis [J] . Ota Koichiro, Yamazaki Ikuma, Saigoku Takahiro, The Journal of Organic Chemistry . 2017,第23期

机译：植物Linteus的晶粒L，SesquiterPene代谢物：隔离，结构阐明和不对称总合成
3. Structure Elucidation and Enantioselective Total Synthesis of the Potent HMG-CoA Reductase Inhibitor FR901512 via Catalytic Asymmetric Nozaki-Hiyama Reactions [J] . Masahiro Inoue, Masahisa Nakada Journal of the American Chemical Society . 2007,第14期

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A concise asymmetric total synthesis for structure elucidation of 5,6-secoiridoid from Incarvillea argute

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