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首页> 外文期刊>Cornea >Identification of oxytalan fibers in Salzmann's nodular degeneration.
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Identification of oxytalan fibers in Salzmann's nodular degeneration.

机译：鉴定Salzmann结节变性中的oxytalan纤维。

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PURPOSE: Diagnosis of Salzmann's nodular degeneration is based on clinical findings, as histopathologic findings in nodules are nonspecific on routine examination. This study demonstrates that presence of oxytalan fibers (ie, elastic system fibers) in lesions of Salzmann's nodular degeneration under light and electron microscopy allows definitive diagnosis. METHODS: A 55-year-old woman noticed white nodular lesions on both corneas. Excised lesion tissues were examined under light microscopy with special staining and transmission electron microscopy. RESULTS: Nodular lesions comprised hyalinized connective tissue showing nonspecific findings on routine histologic examination. However, oxidized aldehyde fuchsin staining yielded positive results in lesions, indicating the presence of oxytalan fibers. Transmission electron microscopy identified bundles of microfibrils in lesions, confirming the presence of oxytalan fibers. CONCLUSIONS: Light microscopic examination by oxidized aldehyde fuchsin staining should be performed when diagnosing Salzmann's nodular degeneration.
机译：目的：萨尔兹曼结节变性的诊断基于临床发现，因为结节的组织病理学发现在常规检查中没有特异性。这项研究表明，在光学和电子显微镜下，Salzmann结节性变性病变中存在氧化金属纤维（即弹性系统纤维）可以进行明确的诊断。方法：一名55岁妇女在两个角膜上均发现白色结节性病变。在光学显微镜下用特殊的染色和透射电子显微镜检查切除的病变组织。结果：结节性病变包括透明化的结缔组织，在常规组织学检查中显示出非特异性发现。但是，氧化醛品红的染色在病变中产生阳性结果，表明存在氧化talan纤维。透射电子显微镜确定了病变中的微纤维束，从而确认了氧化talanan纤维的存在。结论：在诊断萨尔兹曼结节性变性时，应进行氧化醛品红染色的光学显微镜检查。

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