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首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Ectopic Reelin induces neuronal aggregation with a normal birthdate-dependent inside-out
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Ectopic Reelin induces neuronal aggregation with a normal birthdate-dependent inside-out

机译：异位Reelin诱导神经元聚集，其出生日期依赖性由内而外

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摘要

Neurons in the developing mammalian neocortex form the cortical plate (CP) in an inside-out whereas later-born neurons migrate past the existing layers and form the more superficial layers. Reelin, a glycoprotein secreted by Cajal-Retzius neurons in the marginal zone (MZ), is crucial for this "inside-out" layering, because the layers are inverted in the Reelin-deficient mouse, reeler (Reln(rl)). Even though more than a decade has passed since the discovery of reelin, the biological effect of Reelin on individual migrating neurons remains unclear. In addition, although the MZ is missing in the reeler cortex, it is unknown whether Reelin directly regulates the development of the cell-body-sparse MZ. To address these issues, we expressed Reelin ectopically in the developing mouse cortex, and the results showed that Reelin caused the leading processes of migrating neurons to assemble in the Reelin-rich region, which in turn induced their cell bodies to form cellular aggregates around Reelin. Interestingly, the ectopic Reelin-rich region became cell-body-sparse and dendrite-rich, resembling the MZ, and the late-born neurons migrated past their predecessors toward the central Reelin-rich region within the aggregates, resulting in a birthdate-dependent "inside-out" alignment even ectopically. Reelin receptors and intracellular adaptor protein Dab1 were found to be necessary for formation of the aggregates. The above findings indicate that Reelin signaling is capable of inducing the formation of the dendrite-rich, cell-body-sparse MZ and a birthdate-dependent "inside-out" alignment of neurons independently of other factors/structures near the MZ.
机译：发育中的哺乳动物新皮层中的神经元由内而外形成皮层板（CP），而较晚出生的神经元则越过现有的层并形成更浅的层。 Reelin是边缘区域（MZ）中Cajal-Retzius神经元分泌的一种糖蛋白，对于这种“由内而外”的分层至关重要，因为Reelin缺陷小鼠reeler（Reln（rl））中的层是反向的。尽管从reelin的发现已经过去了十多年，但Reelin对单个迁移神经元的生物学作用仍不清楚。另外，尽管在绕线器皮层中缺少MZ，但还不清楚Reelin是否直接调节稀疏细胞体MZ的发育。为了解决这些问题，我们在发育中的小鼠皮层中异位表达了Reelin，结果表明Reelin导致了迁移神经元的主要过程在富含Reelin的区域聚集，进而诱导其细胞体在Reelin周围形成细胞聚集体。 。有趣的是，异位富集Reelin的区域变成了细胞体稀疏和树突状富集的区域，类似于MZ，而后出生的神经元则通过其前辈向聚集体中富集Reelin的中央区域迁移，从而导致出生日期依赖“从里到外”的对齐方式甚至在异位。发现聚集蛋白的形成必需有Reelin受体和细胞内衔接蛋白Dab1。上述发现表明，Reelin信号传导能够诱导树突状富集，细胞体稀疏的MZ的形成以及神经元的出生日期依赖性“由内而外”排列，而与MZ附近的其他因素/结构无关。

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