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Nephropathy in youth and young adults with type 2 diabetes topical collection on pediatric type 2 diabetes

机译:青年和青年人2型糖尿病的肾病局部收集于小儿2型糖尿病

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The occurrence and progression of nephropathy associated with early onset type 2 diabetes (T2D) is a consequence of the ongoing epidemic of childhood obesity. Minimal evidence regarding treatment effectiveness of renovascular comorbidities in youth with early onset T2D is available, due to the relatively recent emergence of T2D in youth and young adults. Extrapolation of adult therapy guidelines is not an ideal approach to making therapeutic decisions in this population. Evolving management and intervention strategies are based on accumulating longitudinal data from cohorts of well characterized youth and young adults with T2D. The degree of similarity in histologic findings and disease specific characteristics of kidney disease in patients with early onset T2D and albuminuria compared with affected adults is not well characterized. Early aggressive therapies to minimize the impact of nephropathy are indicated as the evidence for best therapies in youth with T2D are further explored.
机译:与早期发作的2型糖尿病(T2D)相关的肾病的发生和发展是儿童肥胖病持续流行的结果。由于在年轻人和年轻人中相对较新的T2D出现,因此可获得关于在早期T2D发病的年轻人中肾血管合并症治疗效果的极少证据。成人治疗指南的外推并不是在该人群中做出治疗决定的理想方法。不断发展的管理和干预策略是基于积累了特征明确的T2D青年和年轻人的队列纵向数据。与受影响的成年人相比,早发性T2D和蛋白尿的患者的肾脏病理学发现和疾病特异性特征的相似程度尚不明确。指出了将肾病的影响减至最小的早期积极疗法,这是进一步探索T2D青年最佳疗法的证据。

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