...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Dalton transactions: An international journal of inorganic chemistry >Synthesis and anticancer activity of silver(I)-N-heterocyclic carbene complexes derived from the natural xanthine products caffeine, theophylline and theobromine
【24h】

Synthesis and anticancer activity of silver(I)-N-heterocyclic carbene complexes derived from the natural xanthine products caffeine, theophylline and theobromine

机译：天然黄嘌呤产物咖啡因，茶碱和可可碱衍生的银（I）-N-杂环卡宾配合物的合成及抗癌活性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A new library of silver(I)-N-heterocyclic carbene complexes prepared from the natural products caffeine, theophylline and theobromine is reported. The complexes have been fully characterised using a combination of NMR spectroscopy, mass spectrometry, elemental analysis and X-ray diffraction analysis. Furthermore, the hydrophobicity of the complexes has been measured. The silver(I)-N-heterocyclic carbenes have been evaluated for their antiproliferative properties against a range of cancer cell lines of different histological types, and compared to cisplatin. The data shows different profiles of response when compared to cisplatin in the same panel of cells, indicating a different mechanism of action. Furthermore, it appears that the steric effect of the ligand and the hydrophobicity of the complex both play a role in the chemosensitivity of these compounds, with greater steric bulk and greater hydrophilicity delivering higher cytotoxicity.
机译：报道了由天然产物咖啡因，茶碱和可可碱制备的银（I）-N-杂环卡宾配合物的新库。使用NMR光谱，质谱，元素分析和X射线衍射分析的组合已对复合物进行了充分表征。此外，已经测量了复合物的疏水性。已经评估了银（I）-N-杂环卡宾对多种不同组织学类型的癌细胞系的抗增殖特性，并与顺铂进行了比较。与同一组细胞中的顺铂相比，数据显示了不同的反应曲线，表明了不同的作用机制。此外，似乎配体的空间效应和复合物的疏水性均在这些化合物的化学敏感性中起作用，更大的空间体积和更大的亲水性传递更高的细胞毒性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号