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首页> 外文期刊>International Journal of Biological Macromolecules: Structure, Function and Interactions >Development of reinforced aldehyde-modified kappa-carrageenan/gelatin film by incorporation of halloysite nanotubes for biomedical applications
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Development of reinforced aldehyde-modified kappa-carrageenan/gelatin film by incorporation of halloysite nanotubes for biomedical applications

机译：通过掺入用于生物医学应用的Holloysite Nanotubes，通过掺入增强醛改性的Kappa-carrajetenan /明胶薄膜的研制

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摘要

Recently, with the progression in tissue engineering, the importance of biocompatible nanocomposite film with suitable properties for potential applications in the biomedical area has been more developed. In this work, nanocomposite films of aldehyde-modified Carrageenan/Gelatin/halloysite nanotubes (AD-Carr/Gel/HNTs) nanocomposite films were successfully fabricated by the solution casting process. Halloysite nanotubes (HNTs) with different concentrations (0.5, 1.0, and 1.5 wt%) loaded into the aldehyde-modified Carrageenan/Gelatin (AD-Carr/Gel). Meanwhile, the developed AD-Carr/Gel/HNTs nanocomposite films were characterized by scanning electron microscopy (SEM), thermogravimetric analysis (TGA), mechanical property, water adsorption as well as in vitro degradation. The feasibility and capability of the nanocomposite films were further evaluated by hemocompatibility study, which showed that these nanocomposite films are hemocompatible. Besides, MIT assay revealed that the nanocomposite films are non-toxic, presenting the films as a good candidate to be used for tissue engineering purposes. (C) 2020 Published by Elsevier B.V.
机译：最近，随着组织工程的进展，更大的是生物化纳米复合膜具有合适性的生物相容性纳米复合膜的重要性，更大了。在这项工作中，通过溶液浇铸过程成功制造了醛改性的角烷蛋白/明胶/霍氏素纳米管（Ad-Carr /凝胶/ HNT）纳米复合膜的纳米复合膜。具有不同浓度（0.5,1.0和1.5wt％）的Halloysite Nanotubes（HNT），其装入醛改性的角叉菜蜡蛋白/明胶（Ad-Carr /凝胶）中。同时，通过扫描电子显微镜（SEM），热重分析（TGA），机械性能，水吸附以及体外降解，表征了显影的Ad-Carr /凝胶/ HNT纳米复合膜。通过血液化研究进一步评估纳米复合膜的可行性和能力，表明这些纳米复合膜是血液相处的。此外，麻省理工学院测定显示纳米复合膜是无毒的，将薄膜作为用于组织工程目的的良好候选者。 （c）2020由elsevier b.v发布。

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