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首页> 外文期刊>European Journal of Medicinal Chemistry: Chimie Therapeutique >Synthesis and antioxidant properties of some novel 5H-dibenz(b,f)azepine derivatives in different in vitro model systems.
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Synthesis and antioxidant properties of some novel 5H-dibenz(b,f)azepine derivatives in different in vitro model systems.

机译：不同体外模型系统中某种新型5H-二苯深（B，F）偶氮衍生物的合成及抗氧化性能。

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摘要

A series of 5H-dibenz[b,f]azepine containing different aminophenols and substituted aminophenols were synthesized. 3-chloro-1-(5H-dibenz[b,f]azepine-5yl)propan-1-one (2) was obtained by N-acylation of 5H-dibenz[b,f]azepine (1) with 3-chloro propionyl chloride. Further base condensation with different aminophenols and substituted aminophenols to produce series of 5H-dibenz[b,f]azepine containing aminophenol and substituted aminophenol (2a-e). The structures of newly synthesized compounds were characterized by spectral and elemental analysis. Their antioxidant properties were evaluated by using several methods: scavenging effects on 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical, inhibition of lipid peroxidation using beta-carotene linoleate system, inhibition of human low-density lipoprotein (LDL) oxidation and reducing power. Butylated Hydroxy Anisole (BHA) and Ascorbic acid (AA) were used as the reference antioxidant compounds and also the comparative study with the synthesized compounds was done. Under our experimental conditions, Compound (2) showed negligible activity over all the antioxidant assays but 5H-dibenz[b,f]azepine containing different aminophenols and substituted aminophenols (2a-e) showed good antioxidant activities over all the methods and compounds containing substituted aminophenols 2e and 2d showed predominant antioxidant activities among the synthesized analogues.
机译：合成了一种含有不同氨基苯酚和取代的氨基苯酚的5H-DiBenz [B，F]偶氮细胞。通过用3-氯的5H-二苯肼[B，F]偶氮化（1）的N-酰化，得到3-氯-1-（5H-二苯深[B，F]偶氮-5-1）丙酮-1-一（2），得到3-氯丙酰氯。进一步基于不同氨基酚和取代的氨基苯酚的缩合，以产生含有氨基苯酚和取代的氨基苯酚（2A-E）的含有氨基酚和取代的氨基酚（2A-E）的5H-Dibenz [B，F]偶氮苯酚。通过光谱和元素分析表征新合成化合物的结构。通过使用几种方法评价它们的抗氧化性能：清除效应2,2-二苯基-1-富铬酰基（DPPH）自由基，使用β-胡萝卜素LiNoLeate系统抑制脂质过氧化，抑制人低密度脂蛋白（LDL）氧化和氧化减少力量。用作参考抗氧化剂（AA）和抗坏血酸（AA）作为参考抗氧化剂化合物，并且还完成了与合成化合物的对比研究。在我们的实验条件下，化合物（2）在所有抗氧化剂测定中显示出可忽略的活性，但含有不同氨基苯酚和取代的氨基苯酚（2A-E）的5H-二苯深[B，F]偶氮肠，并在所有含有取代的方法和化合物上显示出良好的抗氧化活性氨基酚2E和2D在合成类似物中显示出主要的抗氧化活性。

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