首页> 外文期刊>European Journal of Medicinal Chemistry: Chimie Therapeutique >Poly(ethylene glycol) (PEG-400) as an alternative reaction solvent for the synthesis of some new 1-(4-(4'-chlorophenyl)-2-thiazolyl)-3-aryl-5-(2-butyl-4-chloro-1H-imidazol-5yl)-2 -pyrazolines and their in vitro antimicrobial evaluation.
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Poly(ethylene glycol) (PEG-400) as an alternative reaction solvent for the synthesis of some new 1-(4-(4'-chlorophenyl)-2-thiazolyl)-3-aryl-5-(2-butyl-4-chloro-1H-imidazol-5yl)-2 -pyrazolines and their in vitro antimicrobial evaluation.

机译:聚(乙二醇)(PEG-400)作为合成一些新的1-(4-(4'-氯苯基)-2-噻唑基)-3-芳基-5-(2-丁基-4的合成的替代反应溶剂 -Chloro-1H-咪唑-5-1)-2-吡唑啉及其体外抗微生物评估。

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摘要

Several 1-(4-(4'-chlorophenyl)-2-thiazolyl)-3-aryl-5-(2-butyl-4-chloro-1H-imidazol-5yl)-2 -pyrazoline derivatives were prepared by the base catalyzed treatment of appropriate chalcones with 4-(4'-chlorophenyl)-2-hydrazino-thiazole in poly (ethylene glycol) (PEG-400) as an alternative reaction solvent. All the synthesized compounds were tested for their antimicrobial activities against Escherichia coli (MTCC 2939), Salmonella typhi (MTCC 98), Staphylococcus aureus (MTCC 96), Bacillus subtilis (MTCC 441), Aspergillus niger (MTCC 281), Trichoderma viridae (MTCC 167), Penicillium chrysogenum (MTCC 160), Fusarium moniliforme (MTCC 156) and Candida albicans (MTCC 183). Most of the compounds showed potent antibacterial and antifungal activity.
机译:通过碱催化制备几种1-(4'-(4'-氯苯基)-2-噻唑基)-3-芳基-5-(2-丁基-4-氯-1H-咪唑-5-2-2-吡唑啉衍生物 用4-(4'-氯苯基)-2-肼噻唑在聚(乙二醇)(PEG-400)中用4-(4'-氯苯基)-2-肼噻唑作为替代反应溶剂处理适当的硫氨酸。 所有合成的化合物都针对对大肠杆菌(MTCC 2939),沙门氏菌Typhi(MTCC 98),金黄色葡萄球菌(MTCC 96),枯草芽孢杆菌(MTCC 441),Aspergillus尼日尔(MTCC 281),Trichoderma viridae(MTCC 167),青霉裂藻(MTCC 160),镰刀菌Moniliforme(MTCC 156)和Candida albicans(MTCC 183)。 大多数化合物显示出有效的抗菌和抗真菌活性。

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