• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>European Journal of Medicinal Chemistry: Chimie Therapeutique >Synthesis and screening of some novel fused thiophene and thienopyrimidine derivatives for anti-avian influenza virus (H5N1) activity.
【24h】

Synthesis and screening of some novel fused thiophene and thienopyrimidine derivatives for anti-avian influenza virus (H5N1) activity.

机译：抗禽流感病毒（H5N1）活性的一些新型融合噻吩和噻吩胺衍生物的合成及筛选。

获取原文
获取原文并翻译 | 示例
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Several derivatives containing dihydronaphtho, naphtho[2,1-b]thiophene and thieno[2,3-d]pyrimidine ring systems were prepared starting from 2-amino-4,5-dihydronaphtho[2,1-b]thiophene-1-carbonitrile (1). Structure characterization of the thioxo derivative 7 was also performed and its reaction with some chloro and bromoalkyl reagents was studied. Moreover, the prepared products were tested for antiviral activity against H5N1 virus [A/chicken/Egypt/1/2006 (H5N1)] by determination of both EC50 and LD50 and confirmed by plaque reduction assay on MDCK cells. Compounds 5, 7 and 8 showed the highest effect compared with the other tested compounds.
机译：从2-氨基-4,5-二氢萘[2,1-B]噻吩-1-开始制备含有二氢萘，萘[2,1-B]噻吩和噻吩并[2,3-D]嘧啶环系统的衍生物。 碳腈（1）。 还进行了硫代氧氧氧氧肟衍生物7的结构，并研究了与一些氯和溴烷基试剂的反应。 此外，通过测定EC50和LD50并通过MDCK细胞上的斑块减少测定证实，对制备的产物进行对H5N1病毒[A /鸡/埃及/ 1/2006（H5N1）]的抗病毒活性进行测试。 与其他测试化合物相比，化合物5,7和8显示了最高效果。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号