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首页> 外文期刊>European Journal of Medicinal Chemistry: Chimie Therapeutique >Review of the molecular mechanisms of Ganoderma lucidum triterpenoids: Ganoderic acids A, C2, D, F, DM, X and Y
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Review of the molecular mechanisms of Ganoderma lucidum triterpenoids: Ganoderic acids A, C2, D, F, DM, X and Y

机译：综述灵芝三萜类化合物的分子机制：Ganoderic酸A，C2，D，F，DM，X和Y.

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摘要

Ganoderma lucidum is a multi-purpose plant medicine that is homologous to functional food. The most attractive properties of G. lucidum are its immunomodulatory and antitumour activities, which are mainly attributed to the following two major active components: G. lucidum polysaccharides and G. lucidum triterpenoids (GLTs). GLTs are effective as supplemental therapies and improve health when combined with other medications to treat hepatitis, fatigue syndrome, and prostate cancer. However, research investigating the mechanism and application of G. lucidum or GLTs in the treatment of diseases remains preliminary in terms of both the utilization efficacy and product type. This review offers comprehensive insight into the pharmacological activities of GLTs and their potential applications in the development of functional foods and nutraceuticals. Specifically, 83 GLTs were selected, and their molecular structures and chemical formulas were described. We also describe 7 ganoderic acids that are currently at different stages of clinical trials (ganoderic acids A, C2, D, F, DM, X and Y). The related pharmacodynamic mechanisms and targeted signalling proteins were further analysed. Notably, the specific relationship between autophagy and apoptosis induced by ganoderic acid DM is summarized here for the first time. (C) 2019 Elsevier Masson SAS. All rights reserved.
机译：Ganoderma lucidum是一种与功能性食品同源的多功能植物药物。 G. lucidum最具吸引力的性质是其免疫调节和抗肿瘤活动，主要归因于以下两个主要的活性组分：G. lucidum多糖和G. lucidum triterpenoids（Glts）。当与其他药物相结合治疗肝炎，疲劳综合征和前列腺癌时，GLTS作为补充疗法有效，改善健康。然而，研究患有G. lucidum或Glts在治疗疾病中的研究的研究仍然是利用疗效和产品类型的初步。本综述提供了对GLTS药理活动的全面洞察力及其在开发功能食品和营养保健品中的潜在应用。具体地，选择了83个GLT，并描述了它们的分子结构和化学式。我们还描述了目前处于临床试验的不同阶段的7种游泳酸（Ganoderic酸A，C2，D，F，DM，X和Y）。进一步分析相关的药效学机制和靶向信号蛋白。值得注意的是，在此首次汇总了Ganoderic酸DM诱导的自噬和凋亡之间的具体关系。 （c）2019年Elsevier Masson SAS。版权所有。

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