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首页> 外文期刊>European Journal of Medicinal Chemistry: Chimie Therapeutique >Tyrosinase inhibitors as potential antibacterial agents
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Tyrosinase inhibitors as potential antibacterial agents

机译：酪氨酸酶抑制剂作为潜在的抗菌剂

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摘要

Tyrosinase is a copper-containing enzyme that catalyzes the biosynthesis of melanin. This enzyme is present in bacteria, fungi, plants and animals, and plays multiple roles in pigmentation, wound healing, radiation protection, primary immune responses and the undesirable browning of fruits and vegetables. Selective tyrosinase inhibitors hence have potential application in diverse areas of agriculture, cosmetics and pharmaceuticals. In the past decade many natural and synthetic tyrosinase inhibitors have been evaluated, with many reported to also possess intrinsic antibacterial activity. Further, the enzyme product melanin has been shown to compromise the activity of traditional antibiotics. Due to the antibiotic resistance crisis and the slow development of new antibiotics, tyrosinase inhibitors may have potential for development of novel antimicrobials or antibiotic adjuvants that enhance activity of incumbent drugs. This review focuses on the antibacterial activity of natural and synthetic tyrosinase inhibitors reported in the past ten years and explores the possibilities for synergism of anti-tyrosinase with anti-bacterials. (C) 2019 Elsevier Masson SAS. All rights reserved.
机译：酪氨酸酶是一种含铜酶，其催化黑色素的生物合成。该酶存在于细菌，真菌，植物和动物中，并在色素沉着，伤口愈合，辐射保护，原发性免疫应答以及水果和蔬菜的不期望的褐变中发挥多种作用。因此选择性的酪氨酸酶抑制剂在农业，化妆品和药品不同领域的应用潜力。在过去的十年中，已经评估了许多天然和合成酪氨酸酶抑制剂，许多据报道还具有内在抗菌活性。此外，已显示酶产物黑色素损害传统抗生素的活性。由于抗生素抗性危机和新抗生素的缓慢，酪氨酸酶抑制剂可能具有开发新的抗微生物或抗生素佐剂的潜力，可增强现有药物的活性。本综述重点介绍了过去十年中报道的天然和合成酪氨酸酶抑制剂的抗菌活性，探讨了抗菌抗菌酶的协同作用的可能性。 （c）2019年Elsevier Masson SAS。版权所有。

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